arl-1 ADP-ribosylation factor-like protein 1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: arl-1
Gene description: ADP-ribosylation factor-like protein 1
Locus tag: CELE_F54C9.10
See related: AllianceGenome:WB:WBGene00000187
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTP binding activity. Involved in positive regulation of nematode male tail tip morphogenesis. Predicted to be active in Golgi apparatus. Is expressed in intestine; nervous system; and tail hypodermis. Orthologous to human ARL1 (ADP ribosylation factor like GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See arl-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 3

Sequence:: Chromosome: II; NC_003280.10 (8582000..8583080)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that ARF-1.1 interacts with NCS-1 in AIY neurons and potentially pifk-1 in the Ca(2+) signaling pathway that leads to inhibited locomotion at an elevated temperature.
Title: Interaction of ARF-1.1 and neuronal calcium sensor-1 in the control of the temperature-dependency of locomotion in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54C9.10 (e-PCR)
- UniSTS:315917

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ADP-ribosylation factor-like protein 1

NP_495816.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8582000..8583080

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063415.7 → NP_495816.1 ADP-ribosylation factor-like protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495816.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20758

Conserved Domains (2) summary

smart00178
Location:7 → 173

SAR; Sar1p-like members of the Ras-family of small GTPases

cd04151
Location:18 → 175

Arl1; ADP ribosylation factor 1 (Arf1)