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suf-1 Suppressor of forked domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174380, updated on 2-Nov-2024

Summary

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Official Symbol
suf-1
Official Full Name
Suppressor of forked domain-containing protein
Primary source
WormBase:WBGene00006307
Locus tag
CELE_F28C6.6
See related
AllianceGenome:WB:WBGene00006307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in RNA 3'-end processing. Predicted to be active in nucleus. Orthologous to human CSTF3 (cleavage stimulation factor subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See suf-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
10
Sequence:
Chromosome: II; NC_003280.10 (8603846..8606744)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Amelotin Neighboring gene Cleavage stimulation factor 50 kDa subunit Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein uL24 Neighboring gene TYR_PHOSPHATASE_2 domain-containing protein Neighboring gene Secreted protein Neighboring gene Centrosomal protein CEP104 N-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Developmental expression pattern of the Caenorhabditis elegans homologue of the Drosophila suppressor of forked gene. Tanaka Y, et al. DNA Res, 1995 Jun 30. PMID 8581741
  2. An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. McCracken S, et al. J Biol Chem, 2003 Nov 7. PMID 12944400
  3. The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Zhang C, et al. Curr Biol, 2012 May 22. PMID 22542102, Free PMC Article
  4. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article
  5. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Suppressor of forked domain-containing protein
NP_495825.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8603846..8606744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063424.8 → NP_495825.1  Suppressor of forked domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495825.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17347, Q18907, Q19866
    Conserved Domains (2) summary
    COG5107
    Location:12 → 502
    RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
    pfam05843
    Location:363 → 651
    Suf; Suppressor of forked protein (Suf)
Nucleotide Protein
Heading Accession and Version

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