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rol-6 Cuticle collagen rol-6 [ Caenorhabditis elegans ]

Gene ID: 174397, updated on 2-Nov-2024

Summary

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Official Symbol
rol-6
Official Full Name
Cuticle collagen rol-6
Primary source
WormBase:WBGene00004397
Locus tag
CELE_T01B7.7
See related
AllianceGenome:WB:WBGene00004397
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
A structural constituent of collagen and cuticulin-based cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Located in collagen and cuticulin-based cuticle extracellular matrix. Is expressed in hypodermis. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 5. Orthologous to human COLQ (collagen like tail subunit of asymmetric acetylcholinesterase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rol-6 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (8733050..8734239)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Intrinsically Disordered Protein, class B Neighboring gene MAP kinase-activated protein kinase mak-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chemotaxis based enrichment for transgenic animals containing the rol-6 marker. Carter J, et al. MicroPubl Biol, 2018 Jun 7. PMID 32550398, Free PMC Article
  2. Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences. Mello CC, et al. EMBO J, 1991 Dec. PMID 1935914, Free PMC Article
  3. Expressional artifact caused by a co-injection marker rol-6 in C. elegans. Jin H, et al. PLoS One, 2019. PMID 31800569, Free PMC Article
  4. Generation of stable transgenic C. elegans using microinjection. Berkowitz LA, et al. J Vis Exp, 2008 Aug 15. PMID 19066505, Free PMC Article
  5. Genetic mapping and manipulation: chapter 7--Making compound mutants. Fay D. WormBook, 2006 Jun 14. PMID 18050457, Free PMC Article

See all (156) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables structural constituent of collagen and cuticulin-based cuticle IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of collagen and cuticulin-based cuticle IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of cuticle IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in collagen and cuticulin-based cuticle extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in collagen and cuticulin-based cuticle extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cuticle collagen rol-6
NP_495858.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8733050..8734239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063457.4 → NP_495858.1  Cuticle collagen rol-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495858.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P20784
    Conserved Domains (2) summary
    pfam01391
    Location:194 → 242
    Collagen; Collagen triple helix repeat (20 copies)
    pfam01484
    Location:9 → 57
    Col_cuticle_N; Nematode cuticle collagen N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20784.1

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