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rha-1 ATP-dependent RNA helicase A;RNA helicase [ Caenorhabditis elegans ]

Gene ID: 174417, updated on 2-Nov-2024

Summary

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Official Symbol
rha-1
Official Full Name
ATP-dependent RNA helicase A;RNA helicase
Primary source
WormBase:WBGene00004355
Locus tag
CELE_T07D4.3
See related
AllianceGenome:WB:WBGene00004355
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP hydrolysis activity; helicase activity; and nucleic acid binding activity. Involved in germ cell development and negative regulation of gene expression, epigenetic. Predicted to be located in centrosome; cytoplasm; and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleolus. Is expressed in germ line and oocyte. Orthologous to human DHX9 (DExH-box helicase 9). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rha-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
15
Sequence:
Chromosome: II; NC_003280.10 (8878496..8883659, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene P53 and DNA damage-regulated protein 1 Neighboring gene RNA helicase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNA helicase A is important for germline transcriptional control, proliferation, and meiosis in C. elegans. Walstrom KM, et al. Mech Dev, 2005 May. PMID 15817227
  2. RG/RGG repeats in the C. elegans homologs of Nucleolin and GAR1 contribute to sub-nucleolar phase separation. Spaulding EL, et al. Nat Commun, 2022 Nov 3. PMID 36329008, Free PMC Article
  3. Germline chromatin. Schaner CE, et al. WormBook, 2006 Jan 24. PMID 18050477, Free PMC Article
  4. Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences. Robert VJ, et al. Genes Dev, 2005 Apr 1. PMID 15774721, Free PMC Article
  5. A targeted RNAi screen for genes involved in chromosome morphogenesis and nuclear organization in the Caenorhabditis elegans germline. Colaiácovo MP, et al. Genetics, 2002 Sep. PMID 12242227, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RHA-1 is a conserved transcription regulation protein that controls germline proliferation and development in C. elegans
    Title: RNA helicase A is important for germline transcriptional control, proliferation, and meiosis in C. elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables double-stranded RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA duplex unwinding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated transcription termination IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in reproductive process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase A;RNA helicase
NP_001360473.1
  • Confirmed by transcript evidence
NP_495890.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8878496..8883659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373779.1 → NP_001360473.1  RNA helicase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WUJ5
    Conserved Domains (5) summary
    COG1643
    Location:337 → 974
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam07717
    Location:1005 → 1087
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    cd19854
    Location:4 → 73
    DSRM_DHX9_rpt1; first double-stranded RNA binding motif of DEAH box protein 9 (DHX9) and similar proteins
    cd19855
    Location:169 → 244
    DSRM_DHX9_rpt2; second double-stranded RNA binding motif of DEAH box protein 9 (DHX9) and similar proteins
    cl28899
    Location:325 → 562
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  2. NM_063489.6 → NP_495890.2  ATP-dependent RNA helicase A [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495890.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22307
    Conserved Domains (6) summary
    smart00358
    Location:6 → 71
    DSRM; Double-stranded RNA binding motif
    smart00847
    Location:847 → 931
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:337 → 974
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:398 → 539
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:649 → 739
    Helicase_C; Helicase conserved C-terminal domain
    pfam07717
    Location:971 → 1086
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22307.3

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