clh-5 Chloride channel protein [Caenorhabditis elegans] -

Summary

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Official Symbol: clh-5
Official Full Name: Chloride channel protein
Primary source: WormBase:WBGene00000532
Locus tag: CELE_C07H4.2
See related: AllianceGenome:WB:WBGene00000532
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable solute:proton antiporter activity and voltage-gated chloride channel activity. Predicted to be involved in chloride transport and proton transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus; early endosome; and synaptic vesicle. Predicted to be integral component of plasma membrane. Is expressed in several structures, including hypodermis; intestine; pharynx; reproductive system; and tail. Human ortholog(s) of this gene implicated in Dent disease; Raynaud-Claes syndrome; X-linked nephrolithiasis type I; X-linked recessive hypophosphatemic rickets; and low molecular weight proteinuria with hypercalciuric nephrocalcinosis. Orthologous to several human genes including CLCN4 (chloride voltage-gated channel 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See clh-5 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 9

Sequence:: Chromosome: II; NC_003280.10 (9094710..9098605, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C07H4.2 (e-PCR)
- UniSTS:307224

T24H10.1 (e-PCR)
- UniSTS:308108

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables voltage-gated chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated chloride channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Chloride channel protein

NP_495940.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9094710..9098605 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063539.6 → NP_495940.1 Chloride channel protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495940.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EGT4, Q9U6W4

Conserved Domains (4) summary

COG0517
Location:650 → 788

CBS; CBS domain [Signal transduction mechanisms]

cd03684
Location:122 → 614

ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

cd04591
Location:653 → 790

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...

pfam00654
Location:206 → 594

Voltage_CLC; Voltage gated chloride channel