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T24H10.1 Putative transcription elongation factor S-II [ Caenorhabditis elegans ]

Gene ID: 174450, updated on 2-Nov-2024

Summary

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Official Symbol
T24H10.1
Official Full Name
Putative transcription elongation factor S-II
Primary source
WormBase:WBGene00012000
Locus tag
CELE_T24H10.1
See related
AllianceGenome:WB:WBGene00012000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anal depressor muscle; body wall musculature; nervous system; pharynx; and reproductive system. Orthologous to several human genes including TCEA1 (transcription elongation factor A1); TCEA2 (transcription elongation factor A2); and TCEA3 (transcription elongation factor A3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See T24H10.1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (9099371..9100569)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene MARVEL domain-containing protein Neighboring gene Chloride channel protein Neighboring gene Uncharacterized protein Neighboring gene Dynein light chain roadblock

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  2. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
  3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA polymerase II preinitiation complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Putative transcription elongation factor S-II
NP_495941.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9099371..9100569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063540.3 → NP_495941.1  Putative transcription elongation factor S-II [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495941.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P52652
    Conserved Domains (4) summary
    smart00510
    Location:146 → 246
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    smart00509
    Location:8 → 83
    TFS2N; Domain in the N-terminus of transcription elongation factor S-II (and elsewhere)
    cd13749
    Location:261 → 307
    Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
    TIGR01385
    Location:4 → 308
    TFSII; transcription elongation factor S-II
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52652.1

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