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jun-1 BZIP domain-containing protein;Transcription factor jun-1 [ Caenorhabditis elegans ]

Gene ID: 174452, updated on 2-Nov-2024

Summary

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Official Symbol
jun-1
Official Full Name
BZIP domain-containing protein;Transcription factor jun-1
Primary source
WormBase:WBGene00012005
Locus tag
CELE_T24H10.7
See related
AllianceGenome:WB:WBGene00012005
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of RNA splicing; and response to starvation. Located in nucleus. Is expressed in several structures, including excretory cell; hermaphrodite gonad; intestine; nervous system; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma; melanoma; and pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit); JUNB (JunB proto-oncogene, AP-1 transcription factor subunit); and JUND (JunD proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See jun-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
13
Sequence:
Chromosome: II; NC_003280.10 (9113157..9132231)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Skp1-related protein Neighboring gene ncRNA Neighboring gene Neuropeptide-Like Protein Neighboring gene Secreted protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. cel-mir-237 and its homologue, hsa-miR-125b, modulate the cellular response to ionizing radiation. Metheetrairut C, et al. Oncogene, 2017 Jan 26. PMID 27321180, Free PMC Article
  2. Bimolecular fluorescence complementation (BiFC) analysis of protein interactions in Caenorhabditis elegans. Hiatt SM, et al. Methods, 2008 Jul. PMID 18586101, Free PMC Article
  3. Lifespan extension by peroxidase and dual oxidase-mediated ROS signaling through pyrroloquinoline quinone in C. elegans. Sasakura H, et al. J Cell Sci, 2017 Aug 1. PMID 28676501
  4. C. elegans nuclear receptor NHR-6 functionally interacts with the jun-1 transcription factor during spermatheca development. Gissendanner CR, et al. Genesis, 2014 Jan. PMID 24178943, Free PMC Article
  5. Global functional analyses of cellular responses to pore-forming toxins. Kao CY, et al. PLoS Pathog, 2011 Mar. PMID 21408619, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that nhr-6 and jun-1 function together to regulate development of the spermatheca and are necessary for generating an organ with the normal number of cells.
    Title: C. elegans nuclear receptor NHR-6 functionally interacts with the jun-1 transcription factor during spermatheca development.
  2. Results provide evidence that C. elegans fos-1 and jun-1 control ovulation, a tightly regulated rhythmic program in animals.
    Title: Caenorhabditis elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to steroid hormone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to toxic substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
BZIP domain-containing protein;Transcription factor jun-1
NP_001022366.1
  • Confirmed by transcript evidence
NP_001022367.1
  • Confirmed by transcript evidence
NP_001022368.1
  • Partially confirmed by transcript evidence
NP_001129827.1
  • Partially confirmed by transcript evidence
NP_001343785.1
  • Confirmed by transcript evidence
NP_001343786.1
  • Confirmed by transcript evidence
NP_001343787.1
  • Confirmed by transcript evidence
NP_001343788.1
  • Confirmed by transcript evidence
NP_001370235.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9113157..9132231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027195.4 → NP_001022366.1  Transcription factor jun-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022366.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B2CXX6, B2CXX7, B2CXX9, B5U8L4, G5EC66, G5ECU7, G5EF64, Q5FC74
    Conserved Domains (2) summary
    cd14696
    Location:246 → 306
    bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
    pfam14796
    Location:82 → 140
    AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal

  2. NM_001027196.5 → NP_001022367.1  Transcription factor jun-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022367.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECU7
    Conserved Domains (2) summary
    cd14696
    Location:226 → 286
    bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
    pfam14796
    Location:62 → 120
    AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal

  3. NM_001356878.3 → NP_001343785.1  BZIP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C3K0
    Conserved Domains (2) summary
    PTZ00266
    Location:136 → 243
    PTZ00266; NIMA-related protein kinase; Provisional
    cd14696
    Location:194 → 254
    bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain

  4. NM_001356879.3 → NP_001343787.1  BZIP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C2T0
    Conserved Domains (2) summary
    PTZ00266
    Location:122 → 229
    PTZ00266; NIMA-related protein kinase; Provisional
    cd14696
    Location:180 → 240
    bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain

  5. NM_001356880.3 → NP_001343788.1  BZIP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C2Y8
    Conserved Domains (2) summary
    PTZ00266
    Location:85 → 192
    PTZ00266; NIMA-related protein kinase; Provisional
    cd14696
    Location:143 → 203
    bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain

  6. NM_001356881.3 → NP_001343786.1  BZIP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C3E7
    Conserved Domains (1) summary
    cd14696
    Location:102 → 162
    bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain

  7. NM_001383910.2 → NP_001370235.1  Transcription factor jun-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd14696
    Location:82 → 142
    bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain

  8. NM_001136355.4 → NP_001129827.1  Transcription factor jun-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129827.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECU7
    Conserved Domains (1) summary
    cd14696
    Location:91 → 151
    bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain

  9. NM_001027197.5 → NP_001022368.1  Transcription factor jun-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022368.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECU7
    Conserved Domains (1) summary
    cd14696
    Location:28 → 88
    bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5ECU7.1

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