pir-1 RNA/RNP complex-1-interacting phosphatase homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pir-1
Official Full Name: RNA/RNP complex-1-interacting phosphatase homolog
Primary source: WormBase:WBGene00011967
Locus tag: CELE_T23G7.5
See related: AllianceGenome:WB:WBGene00011967
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables inorganic triphosphate phosphatase activity. Predicted to be involved in protein dephosphorylation and regulatory ncRNA-mediated gene silencing. Predicted to be located in cytoplasm and nucleus. Orthologous to human DUSP11 (dual specificity phosphatase 11). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pir-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (9177300..9178633)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans.
Title: The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T23G7.4 (e-PCR)
- UniSTS:308098

T23G7.5 (e-PCR)
- UniSTS:310978

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables inorganic triphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RNA/RNP complex-1-interacting phosphatase homolog

NP_495959.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9177300..9178633

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063558.6 → NP_495959.2 RNA/RNP complex-1-interacting phosphatase homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495959.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22707

Conserved Domains (1) summary

pfam00782
Location:65 → 201

DSPc; Dual specificity phosphatase, catalytic domain