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csa-1 WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174474, updated on 2-Nov-2024

Summary

Official Symbol
csa-1
Official Full Name
WD_REPEATS_REGION domain-containing protein
Primary source
WormBase:WBGene00008403
Locus tag
CELE_D2013.3
See related
AllianceGenome:WB:WBGene00008403
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; and transcription-coupled nucleotide-excision repair. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and nucleotide-excision repair complex. Used to study Cockayne syndrome. Human ortholog(s) of this gene implicated in Cockayne syndrome; Cockayne syndrome A; and UV-sensitive syndrome. Orthologous to human ERCC8 (ERCC excision repair 8, CSA ubiquitin ligase complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See csa-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (9317551..9319726, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Acyl-CoA synthetase 7 Neighboring gene Golgi apparatus protein 1 Neighboring gene Tyrosine-protein kinase receptor cam-1 Neighboring gene ncRNA Neighboring gene WD repeat and FYVE domain-containing protein 2 Neighboring gene ncRNA Neighboring gene Ras-related protein rab-39

General protein information

Preferred Names
WD_REPEATS_REGION domain-containing protein
NP_495982.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9317551..9319726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063581.5NP_495982.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495982.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18963
    Conserved Domains (3) summary
    COG2319
    Location:49267
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:5395
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:44264
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...