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mel-11 cGMP-dependent protein kinase interacting domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174484, updated on 2-Nov-2024

Summary

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Official Symbol
mel-11
Official Full Name
cGMP-dependent protein kinase interacting domain-containing protein
Primary source
WormBase:WBGene00003196
Locus tag
CELE_C06C3.1
See related
AllianceGenome:WB:WBGene00003196
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Involved in embryo development and embryonic body morphogenesis. Located in adherens junction and cytoplasm. Is expressed in several structures, including P1; P2; P3; P4; and hypodermal cell. Orthologous to several human genes including PPP1R12B (protein phosphatase 1 regulatory subunit 12B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mel-11 in Genome Data Viewer
Location:
chromosome: II
Exon count:
16
Sequence:
Chromosome: II; NC_003280.10 (9358530..9369099)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Coelomocyte uptake defective protein 15 Neighboring gene ncRNA Neighboring gene Doublecortin domain-containing protein Neighboring gene Secreted protein Neighboring gene FBD domain-containing protein Neighboring gene Secreted protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans mel-11 myosin phosphatase regulatory subunit affects tissue contraction in the somatic gonad and the embryonic epidermis and genetically interacts with the Rac signaling pathway. Wissmann A, et al. Dev Biol, 1999 May 1. PMID 10208747
  2. The minus-end actin capping protein, UNC-94/tropomodulin, regulates development of the Caenorhabditis elegans intestine. Cox-Paulson E, et al. Dev Dyn, 2014 Jun. PMID 24677443, Free PMC Article
  3. Caenorhabditis elegans LET-502 is related to Rho-binding kinases and human myotonic dystrophy kinase and interacts genetically with a homolog of the regulatory subunit of smooth muscle myosin phosphatase to affect cell shape. Wissmann A, et al. Genes Dev, 1997 Feb 15. PMID 9042856
  4. pix-1 controls early elongation in parallel with mel-11 and let-502 in Caenorhabditis elegans. Martin E, et al. PLoS One, 2014. PMID 24732978, Free PMC Article
  5. The role of the formin gene fhod-1 in C. elegans embryonic morphogenesis. Vanneste CA, et al. Worm, 2013 Jul 1. PMID 24778933, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. pix-1 has a role in controlling early elongation in parallel with mel-11 and let-502 in Caenorhabditis elegans
    Title: pix-1 controls early elongation in parallel with mel-11 and let-502 in Caenorhabditis elegans.
  2. Data describe nonmuscle myosins nmy-1 and nmy-2, which are components of the let-502/mel-11 pathway and assist in regulation of embryo elongation in C. elegans.
    Title: The Caenorhabditis elegans nonmuscle myosin genes nmy-1 and nmy-2 function as redundant components of the let-502/Rho-binding kinase and mel-11/myosin phosphatase pathway during embryonic morphogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables enzyme inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cGMP-dependent protein kinase interacting domain-containing protein
NP_001021928.1
  • Confirmed by transcript evidence
NP_001379325.1
  • Confirmed by transcript evidence
NP_001379421.1
  • Confirmed by transcript evidence
NP_495994.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9358530..9369099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393153.1 → NP_001379325.1  cGMP-dependent protein kinase interacting domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGT0
    Conserved Domains (5) summary
    PHA03095
    Location:60 → 280
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:87 → 118
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:62 → 151
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:906 → 1018
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    cd21930
    Location:655 → 701
    IPD_PPP1R12; inhibitory phosphorylation domain of protein phosphatase 1 regulatory subunit 12 (PPP1R12) family

  2. NM_001026757.4 → NP_001021928.1  cGMP-dependent protein kinase interacting domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021928.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECD7
    Conserved Domains (4) summary
    PHA03095
    Location:60 → 280
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:87 → 118
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:62 → 151
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:1011 → 1123
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

  3. NM_001393154.1 → NP_001379421.1  cGMP-dependent protein kinase interacting domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EG29
    Conserved Domains (5) summary
    PHA03095
    Location:60 → 280
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:87 → 118
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:62 → 151
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:855 → 967
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    cd21930
    Location:652 → 698
    IPD_PPP1R12; inhibitory phosphorylation domain of protein phosphatase 1 regulatory subunit 12 (PPP1R12) family

  4. NM_063593.7 → NP_495994.1  cGMP-dependent protein kinase interacting domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495994.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEB3
    Conserved Domains (4) summary
    PHA03095
    Location:60 → 280
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:87 → 118
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:62 → 151
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:903 → 1015
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
Nucleotide Protein
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