gss-1 Glutathione synthetase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gss-1
Official Full Name: Glutathione synthetase
Primary source: WormBase:WBGene00010941
Locus tag: CELE_M176.2
See related: AllianceGenome:WB:WBGene00010941
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glutathione binding activity and glutathione synthase activity. Predicted to be involved in glutathione biosynthetic process. Predicted to be active in cytosol. Is expressed in head; intestine; nervous system; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; glutathione synthetase deficiency of erythrocytes; and glutatione synthetase deficiency with 5-oxoprolinuria. Orthologous to human GSS (glutathione synthetase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gss-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (9414563..9416431, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M176.2 (e-PCR)
- UniSTS:321608

M176.3 (e-PCR)
- UniSTS:318352

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables glutathione binding	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione binding	IEA Inferred from Electronic Annotation more info
enables glutathione synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione synthase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutathione biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Glutathione synthetase

NP_496011.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9414563..9416431 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063610.8 → NP_496011.1 Glutathione synthetase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496011.1

Status: REVIEWED

UniProtKB/TrEMBL

Q21549

Conserved Domains (1) summary

cd00228
Location:14 → 487

eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.