exc-7 RRM domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: exc-7
Official Full Name: RRM domain-containing protein
Primary source: WormBase:WBGene00001368
Locus tag: CELE_F35H8.5
See related: AllianceGenome:WB:WBGene00001368
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables single-stranded RNA binding activity. Involved in several processes, including epithelial cell development; regulation of alternative mRNA splicing, via spliceosome; and regulation of neuron differentiation. Located in nuclear speck. Is expressed in several structures, including excretory cell; neurons; somatic nervous system; tail; and vulva. Orthologous to several human genes including ELAVL4 (ELAV like RNA binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See exc-7 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 7

Sequence:: Chromosome: II; NC_003280.10 (9575970..9581560)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction between mbl-1 and exc-7, double mutants displayed a severely shortened lifespan.
Title: CRISPR-mediated genetic interaction profiling identifies RNA binding proteins controlling metazoan fitness.
Here we combine RNA-seq with in vitro binding assays to study how 4 different C. elegans SFs, ASD-1, FOX-1, MEC-8, and EXC-7, regulate splicing. The 4 SFs chosen all have well-characterised biology and well-studied loss-of-function genetic alleles, and all contain RRM domains
Title: The combinatorial control of alternative splicing in C. elegans.
this study identifies two conserved RNA-binding proteins, UNC-75/CELF and EXC-7/Hu/ELAV, which regulate overlapping networks of splicing events in GABAergic and cholinergic neurons.
Title: A pair of RNA-binding proteins controls networks of splicing events contributing to specialization of neural cell types.
The subnuclear-localized EXC-7 protein acts in parallel to UNC-75 to affect cholinergic synaptic transmission.
Title: Two neuronal, nuclear-localized RNA binding proteins involved in synaptic transmission.
May affect expression of sma-1 and other genes to effect proper development of the excretory canals.
Title: The role of the ELAV homologue EXC-7 in the development of the Caenorhabditis elegans excretory canals.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F35H8.5 (e-PCR)
- UniSTS:321442

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables poly(A) binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(U) RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in epithelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube size	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RRM domain-containing protein

NP_496057.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9575970..9581560

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063656.6 → NP_496057.1 RRM domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496057.1

Status: REVIEWED

UniProtKB/TrEMBL

Q20084

Conserved Domains (4) summary

cd12377
Location:373 → 449

RRM3_Hu; RNA recognition motif 3 in the Hu proteins family

cd12650
Location:41 → 118

RRM1_Hu; RNA recognition motif 1 in the Hu proteins family

cd12652
Location:128 → 206

RRM2_Hu; RNA recognition motif 2 in the Hu proteins family

TIGR01661
Location:39 → 455

ELAV_HUD_SF; ELAV/HuD family splicing factor