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arc-1 E3 ubiquitin-protein ligase arc-1 [ Caenorhabditis elegans ]

Gene ID: 174525, updated on 2-Nov-2024

Summary

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Official Symbol
arc-1
Official Full Name
E3 ubiquitin-protein ligase arc-1
Primary source
WormBase:WBGene00000180
Locus tag
CELE_ZK1320.6
See related
AllianceGenome:WB:WBGene00000180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be active in lysosomal membrane and plasma membrane. Orthologous to human TRIM23 (tripartite motif containing 23). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See arc-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (9674978..9677210)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Transcription initiation factor TFIID subunit 8 Neighboring gene G patch domain and ankyrin repeat-containing protein 1 homolog Neighboring gene Purkinje cell protein 4-like protein 1 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease. Arnoux I, et al. Elife, 2018 Sep 4. PMID 30179155, Free PMC Article
  2. AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. Quevedo C, et al. Curr Biol, 2007 Feb 6. PMID 17276923
  3. Analysis of RING finger genes required for embryogenesis in C. elegans. Moore R, et al. Genesis, 2004 Jan. PMID 14755799
  4. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
  5. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase arc-1
NP_496089.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9674978..9677210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063688.9 → NP_496089.3  E3 ubiquitin-protein ligase arc-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496089.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09654
    Conserved Domains (6) summary
    smart00502
    Location:208 → 339
    BBC; B-Box C-terminal domain
    cd00878
    Location:371 → 526
    Arf_Arl; ADP-ribosylation factor(Arf)/Arf-like (Arl) small GTPases
    TIGR00231
    Location:371 → 526
    small_GTP; small GTP-binding protein domain
    pfam00643
    Location:105 → 149
    zf-B_box; B-box zinc finger
    pfam01442
    Location:201 → 306
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam14634
    Location:6 → 54
    zf-RING_5; zinc-RING finger domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09654.3

Gene LinkOut

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