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nos-3 Nanos-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174535, updated on 2-Nov-2024

Summary

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Official Symbol
nos-3
Official Full Name
Nanos-type domain-containing protein
Primary source
WormBase:WBGene00003785
Locus tag
CELE_Y53C12B.3
See related
AllianceGenome:WB:WBGene00003785
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Involved in positive regulation of meiotic nuclear division. Located in cytoplasm. Is expressed in several structures, including Psub1; Psub2; Psub3; Psub4; and germ line. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nos-3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (9746316..9750462)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene RNA-binding protein pno-1 Neighboring gene U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein Neighboring gene Secreted protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An improved in vivo tethering assay with single molecule FISH reveals that a nematode Nanos enhances reporter expression and mRNA stability. Doenier J, et al. RNA, 2021 Jun. PMID 33727224, Free PMC Article
  2. Repressive translational control in germ cells. Lai F, et al. Mol Reprod Dev, 2013 Aug. PMID 23408501
  3. GLD-3 and control of the mitosis/meiosis decision in the germline of Caenorhabditis elegans. Eckmann CR, et al. Genetics, 2004 Sep. PMID 15454534, Free PMC Article
  4. C. elegans meg-1 and meg-2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival. Kapelle WS, et al. Genesis, 2011 May. PMID 21305687
  5. NANOS-3 and FBF proteins physically interact to control the sperm-oocyte switch in Caenorhabditis elegans. Kraemer B, et al. Curr Biol, 1999 Sep 23. PMID 10508609

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An improved in vivo tethering assay with single molecule FISH reveals that a nematode Nanos enhances reporter expression and mRNA stability.
    Title: An improved in vivo tethering assay with single molecule FISH reveals that a nematode Nanos enhances reporter expression and mRNA stability.
  2. Data indicate that meg-1 and meg-2 differentially interact with the nanos family nos-1, nos-2 and nos-3 for germ cell proliferaiton.
    Title: C. elegans meg-1 and meg-2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival.
  3. nos-3 loss of function mutant suppresses the lethality of par-2 mutants by regulating PAR-6 protein levels.
    Title: PAR-6 levels are regulated by NOS-3 in a CUL-2 dependent manner in Caenorhabditiselegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of meiotic nuclear division IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Nanos-type domain-containing protein
NP_001379360.1
  • Confirmed by transcript evidence
NP_001379361.1
  • Confirmed by transcript evidence
NP_001382696.1
  • Confirmed by transcript evidence
NP_496101.1
  • Partially confirmed by transcript evidence
NP_496102.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9746316..9750462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393165.1 → NP_001379360.1  Nanos-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7R9XMZ3
    Conserved Domains (2) summary
    TIGR01628
    Location:129 → 347
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam05741
    Location:718 → 770
    zf-nanos; Nanos RNA binding domain

  2. NM_001393164.1 → NP_001379361.1  Nanos-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7R9XLP7
    Conserved Domains (2) summary
    TIGR01628
    Location:129 → 347
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam05741
    Location:715 → 767
    zf-nanos; Nanos RNA binding domain

  3. NM_063701.5 → NP_496102.1  Nanos-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496102.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O18217, O18218
    Conserved Domains (2) summary
    TIGR01628
    Location:111 → 329
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam05741
    Location:697 → 749
    zf-nanos; Nanos RNA binding domain

  4. NM_063700.4 → NP_496101.1  Nanos-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496101.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62486
    Conserved Domains (2) summary
    TIGR01628
    Location:111 → 329
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam05741
    Location:700 → 752
    zf-nanos; Nanos RNA binding domain

  5. NM_001395805.1 → NP_001382696.1  Nanos-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7R9XN27
    Conserved Domains (1) summary
    pfam05741
    Location:584 → 636
    zf-nanos; Nanos RNA binding domain
Nucleotide Protein
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