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dtmk-1 Thymidylate kinase [ Caenorhabditis elegans ]

Gene ID: 174553, updated on 2-Nov-2024

Summary

Official Symbol
dtmk-1
Official Full Name
Thymidylate kinase
Primary source
WormBase:WBGene00011272
Locus tag
CELE_R53.2
See related
AllianceGenome:WB:WBGene00011272
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable nucleoside diphosphate kinase activity and thymidylate kinase activity. Predicted to be involved in dTDP biosynthetic process; dTTP biosynthetic process; and dUDP biosynthetic process. Predicted to be active in mitochondrion and nucleus. Orthologous to human DTYMK (deoxythymidylate kinase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See dtmk-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (9962967..9967099, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene PUL domain-containing protein;Ubiquitin fusion degradation protein 3 homolog Neighboring gene FAD synthase;Molybdenum cofactor biosynthesis protein-like region Neighboring gene Zinc finger protein egl-43 Neighboring gene ncRNA Neighboring gene Putative ATP synthase subunit f, mitochondrial Neighboring gene ncRNA Neighboring gene ncRNA

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thymidylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thymidylate kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in dTDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dTDP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in dTTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dTTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in dUDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleoside monophosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Thymidylate kinase
NP_496151.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9962967..9967099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063750.6NP_496151.1  Thymidylate kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496151.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22018
    Conserved Domains (2) summary
    PLN02924
    Location:6202
    PLN02924; thymidylate kinase
    COG0125
    Location:6210
    Tmk; Thymidylate kinase [Nucleotide transport and metabolism]