nrde-2 Nuclear exosome regulator NRDE2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nrde-2
Official Full Name: Nuclear exosome regulator NRDE2
Primary source: WormBase:WBGene00011333
Locus tag: CELE_T01E8.5
See related: AllianceGenome:WB:WBGene00011333
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in regulatory ncRNA-mediated heterochromatin formation and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in nucleus. Is expressed in several structures, including germ line. Orthologous to human NRDE2 (NRDE-2, necessary for RNA interference, domain containing). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nrde-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 13

Sequence:: Chromosome: II; NC_003280.10 (10242596..10247638, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Conserved NRDE-2/MTR-4 Complex Mediates Nuclear RNAi in Caenorhabditis elegans.
Title: A Conserved NRDE-2/MTR-4 Complex Mediates Nuclear RNAi in Caenorhabditis elegans.
results define NRDE-2 as a component of the nuclear RNAi machinery and demonstrate that metazoan siRNAs can silence nuclear-localized RNAs co-transcriptionally
Title: Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription.
Studies indicate that the heritable silencing pathway depends on at least four genes, designated as nuclear RNAi defective 1-4 (nrde-1/2/3/4).
Title: Small RNAs, RNAi and the inheritance of gene silencing in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS2-182 (e-PCR)
- UniSTS:241854

T01E8.5 (e-PCR)
- UniSTS:306634

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of RNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulatory ncRNA-mediated heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear exosome regulator NRDE2

NP_496209.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

10242596..10247638 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063808.7 → NP_496209.1 Nuclear exosome regulator NRDE2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496209.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EG51

Conserved Domains (1) summary

pfam08424
Location:353 → 671

NRDE-2; necessary for RNA interference