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pro-2 Nucleolar complex protein 2 homolog [ Caenorhabditis elegans ]

Gene ID: 174598, updated on 2-Nov-2024

Summary

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Official Symbol
pro-2
Official Full Name
Nucleolar complex protein 2 homolog
Primary source
WormBase:WBGene00007413
Locus tag
CELE_C07E3.2
See related
AllianceGenome:WB:WBGene00007413
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable histone binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and ribosomal large subunit biogenesis. Predicted to be located in nucleus. Predicted to be part of Noc1p-Noc2p complex and Noc2p-Noc3p complex. Predicted to be active in nucleolus and nucleoplasm. Orthologous to human NOC2L (NOC2 like nucleolar associated transcriptional repressor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pro-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
11
Sequence:
Chromosome: II; NC_003280.10 (10339727..10345112, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Intrinsically Disordered Protein, expressed in Pharynx Neighboring gene Activated in Blocked Unfolded protein response;Cysteine rich repeat-containing domain protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Septin and tuftelin-interacting protein 1 homolog;Tuftelin interacting protein N-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ribosome synthesis and MAPK activity modulate ionizing radiation-induced germ cell apoptosis in Caenorhabditis elegans. Eberhard R, et al. PLoS Genet, 2013 Nov. PMID 24278030, Free PMC Article
  2. Alterations in ribosome biogenesis cause specific defects in C. elegans hermaphrodite gonadogenesis. Voutev R, et al. Dev Biol, 2006 Oct 1. PMID 16876152
  3. RSR-2, the Caenorhabditis elegans ortholog of human spliceosomal component SRm300/SRRM2, regulates development by influencing the transcriptional machinery. Fontrodona L, et al. PLoS Genet, 2013 Jun. PMID 23754964, Free PMC Article
  4. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
  5. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in gonadal mesoderm development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Noc1p-Noc2p complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Noc2p-Noc3p complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nucleolar complex protein 2 homolog
NP_496224.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10339727..10345112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063823.6 → NP_496224.2  Nucleolar complex protein 2 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496224.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7UGI7, O17580, O17971, O18163, Q17785
    Conserved Domains (1) summary
    pfam03715
    Location:328 → 630
    Noc2; Noc2p family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O17580.3

Gene LinkOut

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