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stip-1 Septin and tuftelin-interacting protein 1 homolog;Tuftelin interacting protein N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174600, updated on 2-Nov-2024

Summary

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Official Symbol
stip-1
Official Full Name
Septin and tuftelin-interacting protein 1 homolog;Tuftelin interacting protein N-terminal domain-containing protein
Primary source
WormBase:WBGene00007412
Locus tag
CELE_C07E3.1
See related
AllianceGenome:WB:WBGene00007412
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable nucleic acid binding activity. Predicted to be involved in spliceosomal complex disassembly. Predicted to be located in nucleus. Predicted to be part of U2-type post-mRNA release spliceosomal complex. Orthologous to human TFIP11 (tuftelin interacting protein 11). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See stip-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (10347084..10350012, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Nucleolar complex protein 2 homolog Neighboring gene Uncharacterized protein Neighboring gene Phospholipase A2 Neighboring gene DUF223 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional recovery of the germ line following splicing collapse. Cao W, et al. Cell Death Differ, 2022 Apr. PMID 34663906, Free PMC Article
  2. Characterization of STIP, a multi-domain nuclear protein, highly conserved in metazoans, and essential for embryogenesis in Caenorhabditis elegans. Ji Q, et al. Exp Cell Res, 2007 Apr 15. PMID 17289020
  3. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
  4. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
  5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal complex disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal complex disassembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of U2-type post-mRNA release spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Septin and tuftelin-interacting protein 1 homolog;Tuftelin interacting protein N-terminal domain-containing protein
NP_001359529.1
  • Partially confirmed by transcript evidence
NP_496226.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10347084..10350012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373788.1 → NP_001359529.1  Tuftelin interacting protein N-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3R2
    Conserved Domains (1) summary
    pfam12457
    Location:4 → 38
    TIP_N; Tuftelin interacting protein N terminal

  2. NM_063825.7 → NP_496226.2  Septin and tuftelin-interacting protein 1 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496226.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1XDB6, Q17784
    Conserved Domains (4) summary
    pfam01585
    Location:154 → 197
    G-patch; G-patch domain
    pfam07028
    Location:310 → 411
    DUF1319; Protein of unknown function (DUF1319)
    pfam07842
    Location:397 → 673
    GCFC; GC-rich sequence DNA-binding factor-like protein
    pfam12457
    Location:4 → 104
    TIP_N; Tuftelin interacting protein N terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17784.2

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