eif-2A Eukaryotic translation initiation factor 2A [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: eif-2A
Official Full Name: Eukaryotic translation initiation factor 2A
Primary source: WormBase:WBGene00008480
Locus tag: CELE_E04D5.1
See related: AllianceGenome:WB:WBGene00008480
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable nucleic acid binding activity and ribosome binding activity. Involved in positive regulation of gene expression. Predicted to be part of cytosolic small ribosomal subunit. Is expressed in hypodermis; intestine; and nervous system. Orthologous to human EIF2A (eukaryotic translation initiation factor 2A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See eif-2A in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (10416800..10419237)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of eIF5B in the eukaryotic translation initiation factor 2A (eIF2A) mutant background yielded a very severe slow-development phenotype, suggesting that Initiation Factor Five B (eIF5B/iffb-1 ) and eIF2A work together in the same pathway.
Title: eIF2A, an initiator tRNA carrier refractory to eIF2α kinases, functions synergistically with eIF5B.
Isolation and characterization of mutations in eif-2Ba encoding the a-subunit of eIF2B support a conserved role for eIF2Balpha in providing a binding site for phosphorylated eIF2a to inhibit the exchange factor eIF2B catalytic activity that is required for translation initiation
Title: Molecular Determinants of the Regulation of Development and Metabolism by Neuronal eIF2α Phosphorylation in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

E04D5.1 (e-PCR)
- UniSTS:309524

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Eukaryotic translation initiation factor 2A

NP_001379279.1

Confirmed by transcript evidence

NP_496239.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

10416800..10419237

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001393177.1 → NP_001379279.1 Eukaryotic translation initiation factor 2A [Caenorhabditis elegans]

Status: REVIEWED
NM_063838.8 → NP_496239.2 Eukaryotic translation initiation factor 2A [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496239.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19052, Q95ZW6

Conserved Domains (3) summary

pfam08662
Location:218 → 415

eIF2A; Eukaryotic translation initiation factor eIF2A

sd00039
Location:280 → 318

7WD40; WD40 repeat [structural motif]

cl02567
Location:223 → 394

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...