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ccm-3 Programmed cell death protein 10 homolog [ Caenorhabditis elegans ]

Gene ID: 174638, updated on 2-Nov-2024

Summary

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Official Symbol
ccm-3
Official Full Name
Programmed cell death protein 10 homolog
Primary source
WormBase:WBGene00007561
Locus tag
CELE_C14A4.11
See related
AllianceGenome:WB:WBGene00007561
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein kinase binding activity. Involved in several processes, including positive regulation of GTPase activity; positive regulation of endocytic recycling; and regulation of Golgi organization. Located in cytoplasm; cytoplasmic side of apical plasma membrane; and growing cell tip. Is expressed in several structures, including excretory cell; head; intestine; pharynx; and reproductive system. Used to study cerebral cavernous malformation. Human ortholog(s) of this gene implicated in cerebral cavernous malformation 3. Orthologous to human PDCD10 (programmed cell death 10). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ccm-3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (10605717..10607275, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene C6 domain-containing protein Neighboring gene Serpentine receptor class gamma Neighboring gene Transcription initiation factor TFIID subunit 13 Neighboring gene Phosphatidylinositol-glycan biosynthesis class W protein Neighboring gene Protein kinase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Generation and Analysis of CCM Phenotypes in C. elegans. Popiel E, et al. Methods Mol Biol, 2020. PMID 32524554
  2. Interrogating the ccm-3 Gene Network. Lant B, et al. Cell Rep, 2018 Sep 11. PMID 30208312
  3. Novel cytokinetic ring components drive negative feedback in cortical contractility. Bell KR, et al. Mol Biol Cell, 2020 Jul 15. PMID 32491957, Free PMC Article
  4. CentTracker: a trainable, machine-learning-based tool for large-scale analyses of Caenorhabditis elegans germline stem cell mitosis. Zellag RM, et al. Mol Biol Cell, 2021 Apr 19. PMID 33502892, Free PMC Article
  5. The initial expansion of the C. elegans syncytial germ line is coupled to incomplete primordial germ cell cytokinesis. Bauer J, et al. Development, 2021 Sep 15. PMID 34195824, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study establishes CCM-3 as a novel regulator of rachis lumenization and polarity establishment during embryogenesis.
    Title: CCM-3 Promotes C. elegans Germline Development by Regulating Vesicle Trafficking Cytokinesis and Polarity.
  2. GCK-1 works together with CCM-3, a known binding partner, to promote intercellular bridge stability and limit localization of both canonical anillin and non-muscle myosin II (NMM-II) to intercellular bridges
    Title: A Sterile 20 Family Kinase and Its Co-factor CCM-3 Regulate Contractile Ring Proteins on Germline Intercellular Bridges.
  3. CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling.
    Title: CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi reassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growing cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Programmed cell death protein 10 homolog
NP_496290.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10605717..10607275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063889.8 → NP_496290.2  Programmed cell death protein 10 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496290.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17958
    Conserved Domains (1) summary
    pfam06840
    Location:5 → 161
    DUF1241; Protein of unknown function (DUF1241)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17958.2

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