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gbh-1 putative gamma-butyrobetaine dioxygenase [ Caenorhabditis elegans ]

Gene ID: 174648, updated on 2-Nov-2024

Summary

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Official Symbol
gbh-1
Official Full Name
putative gamma-butyrobetaine dioxygenase
Primary source
WormBase:WBGene00001522
Locus tag
CELE_D2089.5
See related
AllianceGenome:WB:WBGene00001522
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable gamma-butyrobetaine dioxygenase activity and iron ion binding activity. Predicted to be involved in carnitine biosynthetic process. Predicted to be active in mitochondrion. Orthologous to human BBOX1 (gamma-butyrobetaine hydroxylase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gbh-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (10690452..10693803, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RRM domain-containing protein Neighboring gene ncRNA Neighboring gene Glycine receptor subunit beta-type 4 Neighboring gene 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 Neighboring gene Putative cuticle collagen 79

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables gamma-butyrobetaine dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carnitine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carnitine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative gamma-butyrobetaine dioxygenase
NP_496305.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10690452..10693803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063904.8 → NP_496305.1  putative gamma-butyrobetaine dioxygenase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496305.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19000
    Conserved Domains (3) summary
    cd00250
    Location:125 → 399
    CAS_like; Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases ...
    TIGR02409
    Location:27 → 410
    carnitine_bodg; gamma-butyrobetaine hydroxylase
    cl01414
    Location:25 → 50
    DUF971; Protein of unknown function (DUF971)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19000.1

Gene LinkOut

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