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dph-2 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 [ Caenorhabditis elegans ]

Gene ID: 174649, updated on 2-Nov-2024

Summary

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Official Symbol
dph-2
Official Full Name
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2
Primary source
WormBase:WBGene00007488
Locus tag
CELE_C09G5.2
See related
AllianceGenome:WB:WBGene00007488
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to contribute to 2-(3-amino-3-carboxypropyl)histidine synthase activity. Predicted to be involved in protein histidyl modification to diphthamide. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in diphthamide deficiency syndrome 2. Orthologous to human DPH2 (diphthamide biosynthesis 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dph-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (10702510..10714297, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene ncRNA Neighboring gene putative gamma-butyrobetaine dioxygenase Neighboring gene Glycine receptor subunit beta-type 4 Neighboring gene Putative cuticle collagen 79 Neighboring gene Cuticle collagen 39 Neighboring gene Putative cuticle collagen 80 Neighboring gene Cuticle collagen bli-1 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Slow Recovery from Inbreeding Depression Generated by the Complex Genetic Architecture of Segregating Deleterious Mutations. Adams PE, et al. Mol Biol Evol, 2022 Jan 7. PMID 34791426, Free PMC Article
  2. Nanoscale patterning of collagens in C. elegans apical extracellular matrix. Adams JRG, et al. Nat Commun, 2023 Nov 18. PMID 37980413, Free PMC Article
  3. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
  4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 2-(3-amino-3-carboxypropyl)histidine synthase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to 2-(3-amino-3-carboxypropyl)histidine synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 4 iron, 4 sulfur cluster binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein histidyl modification to diphthamide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein histidyl modification to diphthamide IEA
Inferred from Electronic Annotation
more info
  
involved_in protein histidyl modification to diphthamide ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
part_of protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2
NP_001254257.1
  • Confirmed by transcript evidence
NP_001254258.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10702510..10714297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267328.3 → NP_001254257.1  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254257.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F5GU80, Q09454
    Conserved Domains (1) summary
    cl19374
    Location:6 → 476
    Diphthamide_syn; Putative diphthamide synthesis protein

  2. NM_001267329.3 → NP_001254258.1  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254258.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09454
    Conserved Domains (1) summary
    cl19374
    Location:1 → 169
    Diphthamide_syn; Putative diphthamide synthesis protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09454.2

Gene LinkOut

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