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vps-11 Vacuolar protein sorting-associated protein 11 homolog [ Caenorhabditis elegans ]

Gene ID: 174661, updated on 2-Nov-2024

Summary

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Official Symbol
vps-11
Official Full Name
Vacuolar protein sorting-associated protein 11 homolog
Primary source
WormBase:WBGene00011067
Locus tag
CELE_R06F6.2
See related
AllianceGenome:WB:WBGene00011067
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in several processes, including endosome organization; vacuole organization; and vesicle docking involved in exocytosis. Predicted to be located in late endosome membrane and lysosomal membrane. Predicted to be part of HOPS complex. Predicted to be active in endosome. Is expressed in gonad. Human ortholog(s) of this gene implicated in dystonia 32 and hypomyelinating leukodystrophy 12. Orthologous to human VPS11 (VPS11 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vps-11 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (10788106..10793493, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Histone RNA hairpin-binding protein Neighboring gene Putative protein tag-209 Neighboring gene SET domain-containing protein 14 Neighboring gene Nucleoporin NUP35

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in Caenorhabditis elegans. Xiao H, et al. Mol Biol Cell, 2009 Jan. PMID 18923146, Free PMC Article
  2. ccz-1 mediates the digestion of apoptotic corpses in C. elegans. Nieto C, et al. J Cell Sci, 2010 Jun 15. PMID 20519582
  3. Caenorhabditis elegans HOPS and CCZ-1 mediate trafficking to lysosome-related organelles independently of RAB-7 and SAND-1. Delahaye JL, et al. Mol Biol Cell, 2014 Apr. PMID 24501423, Free PMC Article
  4. Identification of the switch in early-to-late endosome transition. Poteryaev D, et al. Cell, 2010 Apr 30. PMID 20434987
  5. A pathway for phagosome maturation during engulfment of apoptotic cells. Kinchen JM, et al. Nat Cell Biol, 2008 May. PMID 18425118, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in organelle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuole organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle docking involved in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of HOPS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of HOPS complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of vesicle tethering complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vacuolar protein sorting-associated protein 11 homolog
NP_496322.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10788106..10793493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063921.7 → NP_496322.2  Vacuolar protein sorting-associated protein 11 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496322.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09600
    Conserved Domains (4) summary
    smart00299
    Location:407 → 531
    CLH; Clathrin heavy chain repeat homology
    cd00162
    Location:802 → 845
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00637
    Location:413 → 531
    Clathrin; Region in Clathrin and VPS
    pfam12451
    Location:840 → 882
    VPS11_C; Vacuolar protein sorting protein 11 C terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09600.2

Gene LinkOut

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