npp-19 Nucleoporin NUP35 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: npp-19
Official Full Name: Nucleoporin NUP35
Primary source: WormBase:WBGene00003805
Locus tag: CELE_R06F6.5
See related: AllianceGenome:WB:WBGene00003805
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable phospholipid binding activity. Predicted to be a structural constituent of nuclear pore. Involved in embryo development; nucleus organization; and regulation of exit from mitosis. Located in nuclear envelope. Part of nuclear pore. Is expressed in body wall musculature; nervous system; and pharynx. Orthologous to human NUP35 (nucleoporin 35). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See npp-19 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 7

Sequence:: Chromosome: II; NC_003280.10 (10796653..10798479, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results that Nup35/NPP-19 has an evolutionary conserved role in nuclear envelope formation and function, and that this role is particularly critical during the rapid cell divisions of early embryogenesis.
Title: Early embryonic requirement for nucleoporin Nup35/NPP-19 in nuclear assembly.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R06F6.5 (e-PCR)
- UniSTS:317517

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear pore organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in nucleus organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore central transport channel	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore nuclear basket	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nucleoporin NUP35

NP_496324.1

Confirmed by transcript evidence

NP_496325.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

10796653..10798479 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063923.7 → NP_496324.1 Nucleoporin NUP35 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496324.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O62340, Q09601

Conserved Domains (1) summary

pfam05172
Location:195 → 275

Nup35_RRM; Nup53/35/40-type RNA recognition motif
NM_063924.7 → NP_496325.1 Nucleoporin NUP35 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496325.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09601

Conserved Domains (1) summary

pfam05172
Location:195 → 275

Nup35_RRM; Nup53/35/40-type RNA recognition motif