nuo-1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nuo-1
Official Full Name: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Primary source: WormBase:WBGene00003831
Locus tag: CELE_C09H10.3
See related: AllianceGenome:WB:WBGene00003831
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable several functions, including 4 iron, 4 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and nucleotide binding activity. Involved in several processes, including dauer exit; determination of adult lifespan; and inductive cell migration. Located in mitochondrion. Used to study mitochondrial complex I deficiency and mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 4. Orthologous to human NDUFV1 (NADH:ubiquinone oxidoreductase core subunit V1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nuo-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (11097837..11100146)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate that nuo-1 and mitochondrial respiratory chain function in the nervous system is needed to send and receive signals that control larval development and exit from dauer.
Title: Caenorhabditis elegans development requires mitochondrial function in the nervous system.
catalytic deficiency of complexes I & IV in nuo-1 mutants are due to impaired assembly or stability; mutants have reduced levels of fully assembled complex I & assembly intermediates; riboflavin stabilizes steady-state levels of NUO-1
Title: Riboflavin enhances the assembly of mitochondrial cytochrome c oxidase in C. elegans NADH-ubiquinone oxidoreductase mutants.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C09H10.4 (e-PCR)
- UniSTS:320778

C09H10.3 (e-PCR)
- UniSTS:309031

C09H10.2 (e-PCR)
- UniSTS:315470

STS2-15 (e-PCR)
- UniSTS:241818

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables FMN binding	IEA Inferred from Electronic Annotation more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADH dehydrogenase (ubiquinone) activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer exit	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defecation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inductive cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial electron transport, NADH to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, NADH to ubiquinone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial respiratory chain complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex I	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

NP_496376.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11097837..11100146

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063975.5 → NP_496376.1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496376.1

Status: REVIEWED

UniProtKB/TrEMBL

Q17880

Conserved Domains (4) summary

PRK13596
Location:46 → 465

PRK13596; NADH dehydrogenase I subunit F; Provisional

pfam01512
Location:91 → 260

Complex1_51K; Respiratory-chain NADH dehydrogenase 51 Kd subunit

pfam10531
Location:286 → 336

SLBB; SLBB domain

pfam10589
Location:377 → 458

NADH_4Fe-4S; NADH-ubiquinone oxidoreductase-F iron-sulfur binding region