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saps-1 Serine/threonine-protein phosphatase 6 regulatory subunit [ Caenorhabditis elegans ]

Gene ID: 174725, updated on 2-Nov-2024

Summary

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Official Symbol
saps-1
Official Full Name
Serine/threonine-protein phosphatase 6 regulatory subunit
Primary source
WormBase:WBGene00008166
Locus tag
CELE_C47G2.5
See related
AllianceGenome:WB:WBGene00008166
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein phosphatase binding activity. Involved in cortical actin cytoskeleton organization; establishment of mitotic spindle localization; and first cell cycle pseudocleavage. Located in astral microtubule and cell cortex. Orthologous to several human genes including PPP6R3 (protein phosphatase 6 regulatory subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See saps-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
10
Sequence:
Chromosome: II; NC_003280.10 (11297688..11301260)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GTP-binding protein Neighboring gene Transmembrane protein 201 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Aurora A kinase regulates proper spindle positioning in C. elegans and in human cells. Kotak S, et al. J Cell Sci, 2016 Aug 1. PMID 27335426, Free PMC Article
  2. Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos. Afshar K, et al. Development, 2010 Jan. PMID 20040490, Free PMC Article
  3. The PP2A/4/6 subfamily of phosphoprotein phosphatases regulates DAF-16 and confers resistance to environmental stress in postreproductive adult C. elegans. Rivard RS, et al. PLoS One, 2020. PMID 33315870, Free PMC Article
  4. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article
  5. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of mitotic spindle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in first cell cycle pseudocleavage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in astral microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Serine/threonine-protein phosphatase 6 regulatory subunit
NP_001122596.1
  • Confirmed by transcript evidence
NP_001122597.1
  • Confirmed by transcript evidence
NP_496414.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11297688..11301260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129124.5 → NP_001122596.1  Serine/threonine-protein phosphatase 6 regulatory subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122596.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5Z2S4
    Conserved Domains (1) summary
    pfam04499
    Location:129 → 508
    SAPS; SIT4 phosphatase-associated protein

  2. NM_064013.7 → NP_496414.2  Serine/threonine-protein phosphatase 6 regulatory subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496414.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18696
    Conserved Domains (1) summary
    pfam04499
    Location:129 → 508
    SAPS; SIT4 phosphatase-associated protein

  3. NM_001129125.3 → NP_001122597.1  Serine/threonine-protein phosphatase 6 regulatory subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122597.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5Z2S4, B2D6K9, Q18696
    Conserved Domains (1) summary
    pfam04499
    Location:129 → 510
    SAPS; SIT4 phosphatase-associated protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2D6K9.1

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