rsf-1 Ras association domain-containing protein 1 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rsf-1
Official Full Name: Ras association domain-containing protein 1 homolog
Primary source: WormBase:WBGene00011995
Locus tag: CELE_T24F1.3
See related: AllianceGenome:WB:WBGene00011995
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables small GTPase binding activity. Involved in several processes, including chromosome condensation; positive regulation of response to oxidative stress; and regulation of vulval development. Predicted to be located in cytoplasm and microtubule. Is expressed in neurons; pharynx; and vulva. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including RASSF1 (Ras association domain family member 1) and RASSF5 (Ras association domain family member 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rsf-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 10

Sequence:: Chromosome: II; NC_003280.10 (11306399..11311942)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

T24F1.3/rasf-1 directly interacts with rab-39.
Title: C. elegans Rassf homolog, rasf-1, is functionally associated with rab-39 Rab GTPase in oxidative stress response.
Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1. [
Title: Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS2-190 (e-PCR)
- UniSTS:241863

T24F1.3 (e-PCR)
- UniSTS:315093

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of embryonic epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ras association domain-containing protein 1 homolog

NP_001022361.1

Confirmed by transcript evidence

NP_001370200.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11306399..11311942

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027190.5 → NP_001022361.1 Ras association domain-containing protein 1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022361.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22744, Q58AA9

Conserved Domains (3) summary

cd01778
Location:358 → 494

RA_RASSF1_like; Ras-associating (RA) domain found in Ras-association domain family members, RASSF1, RASSF3, and RASSF5

pfam16517
Location:504 → 542

Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

cd20885
Location:163 → 215

C1_RASSF1; protein kinase C conserved region 1 (C1 domain) found in Ras association domain-containing protein 1 (RASSF1) and similar proteins
NM_001383950.2 → NP_001370200.1 Ras association domain-containing protein 1 homolog [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

cd01778
Location:297 → 433

RA_RASSF1_like; Ras-associating (RA) domain found in Ras-association domain family members, RASSF1, RASSF3, and RASSF5

pfam16517
Location:443 → 481

Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

cd20885
Location:102 → 154

C1_RASSF1; protein kinase C conserved region 1 (C1 domain) found in Ras association domain-containing protein 1 (RASSF1) and similar proteins