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tag-180 VWFA domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174730, updated on 2-Nov-2024

Summary

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Official Symbol
tag-180
Official Full Name
VWFA domain-containing protein
Primary source
WormBase:WBGene00007041
Locus tag
CELE_T24F1.6
See related
AllianceGenome:WB:WBGene00007041
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable voltage-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated calcium channel complex. Is expressed in head neurons; intestine; and tail neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 110. Orthologous to human CACNA2D1 (calcium voltage-gated channel auxiliary subunit alpha2delta 1) and CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tag-180 in Genome Data Viewer
Location:
chromosome: II
Exon count:
19
Sequence:
Chromosome: II; NC_003280.10 (11323047..11329429, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene EGF-like domain-containing protein Neighboring gene ncRNA Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene tRNA-Ala Neighboring gene ncRNA Neighboring gene tRNA-Ala

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effects of voltage-gated calcium channel subunit genes on calcium influx in cultured C. elegans mechanosensory neurons. Frøkjaer-Jensen C, et al. J Neurobiol, 2006 Sep 1. PMID 16838374
  2. The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology. Caylor RC, et al. Neural Dev, 2013 May 10. PMID 23663262, Free PMC Article
  3. The alpha1 subunit EGL-19, the alpha2/delta subunit UNC-36, and the beta subunit CCB-1 underlie voltage-dependent calcium currents in Caenorhabditis elegans striated muscle. Lainé V, et al. J Biol Chem, 2011 Oct 21. PMID 21878625, Free PMC Article
  4. Distinct Neural Circuits Control Rhythm Inhibition and Spitting by the Myogenic Pharynx of C. elegans. Bhatla N, et al. Curr Biol, 2015 Aug 17. PMID 26212880, Free PMC Article
  5. Nicotine Motivated Behavior in C. elegans. Salim C, et al. Int J Mol Sci, 2024 Jan 29. PMID 38338915, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
VWFA domain-containing protein
NP_001022363.1
  • Confirmed by transcript evidence
NP_001022364.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11323047..11329429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027193.5 → NP_001022364.1  VWFA domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022364.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EG74
    Conserved Domains (3) summary
    cd01463
    Location:220 → 411
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam08399
    Location:106 → 201
    VWA_N; VWA N-terminal
    pfam02743
    Location:430 → 517
    dCache_1; Cache domain

  2. NM_001027192.6 → NP_001022363.1  VWFA domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022363.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGL3
    Conserved Domains (3) summary
    cd01463
    Location:220 → 411
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam08399
    Location:106 → 201
    VWA_N; VWA N-terminal
    pfam02743
    Location:430 → 517
    dCache_1; Cache domain
Nucleotide Protein
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