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dph-5 diphthine methyl ester synthase [ Caenorhabditis elegans ]

Gene ID: 174737, updated on 2-Nov-2024

Summary

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Official Symbol
dph-5
Official Full Name
diphthine methyl ester synthase
Primary source
WormBase:WBGene00007194
Locus tag
CELE_B0491.7
See related
AllianceGenome:WB:WBGene00007194
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable diphthine methyl ester synthase activity. Predicted to be involved in methylation and protein histidyl modification to diphthamide. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties. Orthologous to human DPH5 (diphthamide biosynthesis 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dph-5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (11350192..11351373)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene DNA helicase Neighboring gene GPI mannosyltransferase 1 Neighboring gene Chloride channel protein Neighboring gene ncRNA Neighboring gene HEME_HALOPEROXIDASE domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables diphthine methyl ester synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein histidyl modification to diphthamide IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
diphthine methyl ester synthase
NP_496427.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11350192..11351373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064026.2 → NP_496427.1  diphthine methyl ester synthase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496427.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17514
    Conserved Domains (1) summary
    PTZ00175
    Location:1 → 273
    PTZ00175; diphthine synthase; Provisional
Nucleotide Protein
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