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mfn-1 Mitoferrin [ Caenorhabditis elegans ]

Gene ID: 174752, updated on 2-Nov-2024

Summary

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Official Symbol
mfn-1
Official Full Name
Mitoferrin
Primary source
WormBase:WBGene00012204
Locus tag
CELE_W02B12.9
See related
AllianceGenome:WB:WBGene00012204
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ferrous iron transmembrane transporter activity. Predicted to be involved in iron import into the mitochondrion. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrial membrane. Is expressed in intestine and nervous system. Orthologous to several human genes including SLC25A28 (solute carrier family 25 member 28). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mfn-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (11470003..11472016, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase-activating protein 68F;Rho-GAP domain-containing protein Neighboring gene Kinesin motor domain-containing protein Neighboring gene CDGSH iron-sulfur domain-containing protein 2 homologue;Iron-binding zinc finger CDGSH type domain-containing protein Neighboring gene tRNA (guanine-N(7)-)-methyltransferase Neighboring gene Beta-1,4-N-acetylgalactosaminyltransferase Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitoferrin-1 is Involved in the Progression of Alzheimer's Disease Through Targeting Mitochondrial Iron Metabolism in a Caenorhabditis elegans Model of Alzheimer's Disease. Huang J, et al. Neuroscience, 2018 Aug 10. PMID 29908215
  2. Reduction of mitoferrin results in abnormal development and extended lifespan in Caenorhabditis elegans. Ren Y, et al. PLoS One, 2012. PMID 22253756, Free PMC Article
  3. The activation of protein homeostasis protective mechanisms perhaps is not responsible for lifespan extension caused by deficiencies of mitochondrial proteins in C. elegans. Ren Y, et al. Exp Gerontol, 2015 May. PMID 25769692
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reduced mitoferrin levels in C. elegans by RNA interference treatment causes pleiotropic phenotypes such as small body size, reduced fecundity, slow movement and increased sensitivity to paraquat.
    Title: Reduction of mitoferrin results in abnormal development and extended lifespan in Caenorhabditis elegans.
  2. These results confirm that knockdown of mitoferrin-1 can slow the progress of disease in Alzheimer model of C. elegans and suggest that mitoferrin-1 plays a major role in mediating mitochondrial iron metabolism in this process.
    Title: Mitoferrin-1 is Involved in the Progression of Alzheimer's Disease Through Targeting Mitochondrial Iron Metabolism in a Caenorhabditis elegans Model of Alzheimer's Disease.
  3. The GCN-2 pathway was not required for the longevity phenotype of mfn-1 worms.
    Title: The activation of protein homeostasis protective mechanisms perhaps is not responsible for lifespan extension caused by deficiencies of mitochondrial proteins in C. elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ferrous iron transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in iron import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mitoferrin
NP_001382726.1
  • Partially confirmed by transcript evidence
NP_001391079.1
  • Partially confirmed by transcript evidence
NP_001391080.1
  • Partially confirmed by transcript evidence
NP_496447.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11470003..11472016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064046.7 → NP_496447.1  Mitoferrin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496447.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23125
    Conserved Domains (1) summary
    pfam00153
    Location:14 → 108
    Mito_carr; Mitochondrial carrier protein

  2. NM_001404239.1 → NP_001391079.1  Mitoferrin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D9I609

  3. NM_001404240.1 → NP_001391080.1  Mitoferrin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D9I610

  4. NM_001395808.1 → NP_001382726.1  Mitoferrin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D9I8L7
    Conserved Domains (1) summary
    PTZ00168
    Location:22 → 193
    PTZ00168; mitochondrial carrier protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23125.1

Gene LinkOut

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