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hacl-1 2-hydroxyacyl-CoA lyase [ Caenorhabditis elegans ]

Gene ID: 174758, updated on 2-Nov-2024

Summary

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Official Symbol
hacl-1
Official Full Name
2-hydroxyacyl-CoA lyase
Primary source
WormBase:WBGene00007143
Locus tag
CELE_B0334.3
See related
AllianceGenome:WB:WBGene00007143
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable thiamine pyrophosphate binding activity. Predicted to be involved in fatty acid alpha-oxidation. Predicted to be active in peroxisome. Orthologous to human HACL1 (2-hydroxyacyl-CoA lyase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hacl-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (11489607..11492963, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Potassium channel domain-containing protein Neighboring gene ncRNA Neighboring gene Transthyretin-like family protein Neighboring gene FMRF-Like Peptide Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Chloride channel CLIC-like protein 1 Neighboring gene PRELI/MSF1 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative metabolomics with Metaboseek reveals functions of a conserved fat metabolism pathway in C. elegans. Helf MJ, et al. Nat Commun, 2022 Feb 10. PMID 35145075, Free PMC Article
  2. A UPR-independent infection-specific role for a BiP/GRP78 protein in the control of antimicrobial peptide expression in C. elegans epidermis. Couillault C, et al. Virulence, 2012 May 1. PMID 22546897, Free PMC Article
  3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables thiamine pyrophosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiamine pyrophosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid alpha-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
2-hydroxyacyl-CoA lyase
NP_001379093.1
  • Confirmed by transcript evidence
NP_496454.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11489607..11492963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064053.6 → NP_496454.1  2-hydroxyacyl-CoA lyase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496454.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17474
    Conserved Domains (4) summary
    PRK09259
    Location:68 → 615
    PRK09259; putative oxalyl-CoA decarboxylase; Validated
    cd02004
    Location:434 → 616
    TPP_BZL_OCoD_HPCL; Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL ...
    pfam00205
    Location:261 → 391
    TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain
    pfam02776
    Location:74 → 240
    TPP_enzyme_N; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain

  2. NM_001393195.1 → NP_001379093.1  2-hydroxyacyl-CoA lyase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17475
    Conserved Domains (1) summary
    PRK09259
    Location:2 → 544
    PRK09259; putative oxalyl-CoA decarboxylase; Validated
Nucleotide Protein
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