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ooc-3 Chloride channel CLIC-like protein 1 [ Caenorhabditis elegans ]

Gene ID: 174759, updated on 18-Sep-2024

Summary

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Official Symbol
ooc-3
Official Full Name
Chloride channel CLIC-like protein 1
Primary source
WormBase:WBGene00003868
Locus tag
CELE_B0334.11
See related
AllianceGenome:WB:WBGene00003868
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chloride channel activity. Involved in embryo development; establishment of mitotic spindle orientation; and protein localization. Located in endoplasmic reticulum. Is expressed in P0. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ooc-3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (11493159..11495321, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene FMRF-Like Peptide Neighboring gene 2-hydroxyacyl-CoA lyase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PRELI/MSF1 domain-containing protein Neighboring gene Membrane magnesium transporter Neighboring gene Phytoene synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. OOC-3, a novel putative transmembrane protein required for establishment of cortical domains and spindle orientation in the P(1) blastomere of C. elegans embryos. Pichler S, et al. Development, 2000 May. PMID 10769231
  2. The Caenorhabditis elegans polarity gene ooc-5 encodes a Torsin-related protein of the AAA ATPase superfamily. Basham SE, et al. Development, 2001 Nov. PMID 11714689
  3. Mutations in ooc-5 and ooc-3 disrupt oocyte formation and the reestablishment of asymmetric PAR protein localization in two-cell Caenorhabditis elegans embryos. Basham SE, et al. Dev Biol, 1999 Nov 15. PMID 10545235
  4. Maternal-effect lethal mutations on linkage group II of Caenorhabditis elegans. Kemphues KJ, et al. Genetics, 1988 Dec. PMID 3224814, Free PMC Article
  5. RAB-11 permissively regulates spindle alignment by modulating metaphase microtubule dynamics in Caenorhabditis elegans early embryos. Zhang H, et al. Mol Biol Cell, 2008 Jun. PMID 18385514, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of cell polarity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Chloride channel CLIC-like protein 1
NP_496456.1
  • Confirmed by transcript evidence
NP_871910.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11493159..11495321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064055.4 → NP_496456.1  Chloride channel CLIC-like protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496456.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XVW6

  2. NM_182110.3 → NP_871910.1  Chloride channel CLIC-like protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871910.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I132
Nucleotide Protein
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