U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

alh-8 putative methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial [ Caenorhabditis elegans ]

Gene ID: 174800, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
alh-8
Official Full Name
putative methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
Primary source
WormBase:WBGene00000114
Locus tag
CELE_F13D12.4
See related
AllianceGenome:WB:WBGene00000114
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity. Predicted to be involved in thymine catabolic process and valine catabolic process. Located in mitochondrion. Orthologous to human ALDH6A1 (aldehyde dehydrogenase 6 family member A1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See alh-8 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (11729055..11731198)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene L-lactate dehydrogenase Neighboring gene Transmembrane protein Neighboring gene Col_cuticle_N domain-containing protein Neighboring gene Serine carboxypeptidase ctsa-1.2 Neighboring gene Guanine nucleotide-binding protein subunit beta-1;WD_REPEATS_REGION domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans. Watson E, et al. Elife, 2016 Jul 6. PMID 27383050, Free PMC Article
  2. C. elegans as a model for inter-individual variation in metabolism. Fox BW, et al. Nature, 2022 Jul. PMID 35794472, Free PMC Article
  3. Mediator subunit MDT-15 promotes expression of propionic acid breakdown genes to prevent embryonic lethality in Caenorhabditis elegans. Goh GYS, et al. G3 (Bethesda), 2023 Jun 1. PMID 37075089, Free PMC Article
  4. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Haynes CM, et al. Mol Cell, 2010 Feb 26. PMID 20188671, Free PMC Article
  5. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables malonate-semialdehyde dehydrogenase (acetylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity IEA
Inferred from Electronic Annotation
more info
  
enables methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in thymine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thymine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in valine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in valine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
putative methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
NP_001022078.1
  • Confirmed by transcript evidence
NP_001022079.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11729055..11731198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026907.5 → NP_001022078.1  putative methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022078.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P52713
    Conserved Domains (2) summary
    cd07085
    Location:30 → 506
    ALDH_F6_MMSDH; Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2
    PLN02466
    Location:18 → 502
    PLN02466; aldehyde dehydrogenase family 2 member

  2. NM_001026908.7 → NP_001022079.1  putative methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022079.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JMI1
    Conserved Domains (1) summary
    cl11961
    Location:30 → 87
    ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52713.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous