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patr-1 Protein PAT1 homolog 1 [ Caenorhabditis elegans ]

Gene ID: 174808, updated on 2-Nov-2024

Summary

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Official Symbol
patr-1
Official Full Name
Protein PAT1 homolog 1
Primary source
WormBase:WBGene00009661
Locus tag
CELE_F43G6.9
See related
AllianceGenome:WB:WBGene00009661
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Involved in determination of adult lifespan. Located in P-body. Orthologous to human PATL1 (PAT1 homolog 1, processing body mRNA decay factor) and PATL2 (PAT1 homolog 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See patr-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (11774668..11777943, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ATP synthase subunit e, mitochondrial Neighboring gene DNA replication ATP-dependent helicase/nuclease Neighboring gene Neuropeptide-Like Protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA topoisomerase 2-associated proteins PATL1 and PATL2 regulate the biogenesis of hERG K(+) channels. Yao L, et al. Proc Natl Acad Sci U S A, 2023 Jan 10. PMID 36608291, Free PMC Article
  2. ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans. Sengupta MS, et al. J Cell Sci, 2013 Feb 1. PMID 23264733, Free PMC Article
  3. Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis. Boag PR, et al. J Cell Biol, 2008 Aug 11. PMID 18695045, Free PMC Article
  4. The mRNA Decay Factor CAR-1/LSM14 Regulates Axon Regeneration via Mitochondrial Calcium Dynamics. Tang NH, et al. Curr Biol, 2020 Mar 9. PMID 31983639, Free PMC Article
  5. Diverse functions of mRNA metabolism factors in stress defense and aging of Caenorhabditis elegans. Rousakis A, et al. PLoS One, 2014. PMID 25061667, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in P-body assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
Inferred from Electronic Annotation
more info
  
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in P-body IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein PAT1 homolog 1
NP_496514.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11774668..11777943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064113.7 → NP_496514.1  Protein PAT1 homolog 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496514.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20374
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20374.2

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