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vab-23 C4H2-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174826, updated on 2-Nov-2024

Summary

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Official Symbol
vab-23
Official Full Name
C4H2-type domain-containing protein
Primary source
WormBase:WBGene00014153
Locus tag
CELE_ZK930.3
See related
AllianceGenome:WB:WBGene00014153
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in several processes, including embryonic body morphogenesis; epidermis morphogenesis; and vulval development. Located in nuclear speck. Is expressed in several structures, including hermaphrodite somatic gonadal cell; ventral uterine precursor; vulval cell; vulval muscle; and vulval precursor cell. Human ortholog(s) of this gene implicated in Miles-Carpenter syndrome. Orthologous to human ZC4H2 (zinc finger C4H2-type containing). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vab-23 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (11897365..11901210, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene C4H2-type domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene non-specific serine/threonine protein kinase Neighboring gene RGS domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The conserved zinc finger protein VAB-23 is an essential regulator of epidermal morphogenesis in Caenorhabditis elegans. Pellegrino MW, et al. Dev Biol, 2009 Dec 1. PMID 19799893
  2. The transcription factor VAB-23 links vulval cell fate specification and morphogenesis. Pellegrino MW, et al. Worm, 2012 Jul 1. PMID 24058843, Free PMC Article
  3. LIN-39 and the EGFR/RAS/MAPK pathway regulate C. elegans vulval morphogenesis via the VAB-23 zinc finger protein. Pellegrino MW, et al. Development, 2011 Nov. PMID 21989912
  4. A protein-protein interaction map of the Caenorhabditis elegans 26S proteasome. Davy A, et al. EMBO Rep, 2001 Sep. PMID 11559592, Free PMC Article
  5. Protein interaction mapping in C. elegans using proteins involved in vulval development. Walhout AJ, et al. Science, 2000 Jan 7. PMID 10615043

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the C. elegans hox gene lin-39 regulates epidermal morphogenesis via its novel target, the essential zinc finger protein VAB-23.
    Title: LIN-39 and the EGFR/RAS/MAPK pathway regulate C. elegans vulval morphogenesis via the VAB-23 zinc finger protein.
  2. Data show that the vab-23 gene (annotated by the C. elegans Genome Sequencing Consortium as ZK930.3) is essential for embryogenesis.
    Title: The conserved zinc finger protein VAB-23 is an essential regulator of epidermal morphogenesis in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epidermis morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
C4H2-type domain-containing protein
NP_001022535.1
  • Confirmed by transcript evidence
NP_001022536.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11897365..11901210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027364.6 → NP_001022535.1  C4H2-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022535.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23664
    Conserved Domains (1) summary
    pfam10146
    Location:23 → 251
    zf-C4H2; Zinc finger-containing protein

  2. NM_001027365.2 → NP_001022536.1  C4H2-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022536.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q65ZB3
    Conserved Domains (1) summary
    pfam10146
    Location:4 → 193
    zf-C4H2; Zinc finger-containing protein
Nucleotide Protein
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