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lin-29 C2H2-type domain-containing protein;Zinc finger transcription factor lin-29 [ Caenorhabditis elegans ]

Gene ID: 174830, updated on 2-Nov-2024

Summary

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Official Symbol
lin-29
Official Full Name
C2H2-type domain-containing protein;Zinc finger transcription factor lin-29
Primary source
WormBase:WBGene00003015
Locus tag
CELE_W03C9.4
See related
AllianceGenome:WB:WBGene00003015
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including collagen biosynthetic process; regulation of gene expression; and regulation of nematode larval development. Located in nucleus. Is expressed in several structures, including R2_hyp; gonad; hypodermis; neurons; and proctodeal cell. Orthologous to human ZNF362 (zinc finger protein 362). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lin-29 in Genome Data Viewer
Location:
chromosome: II
Exon count:
11
Sequence:
Chromosome: II; NC_003280.10 (11917643..11935340, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene non-specific serine/threonine protein kinase Neighboring gene RGS domain-containing protein Neighboring gene High mobility group protein hmg-12 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mapping and analysis of Caenorhabditis elegans transcription factor sequence specificities. Narasimhan K, et al. Elife, 2015 Apr 23. PMID 25905672, Free PMC Article
  2. Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development. Wightman B, et al. Genes Dev, 1991 Oct. PMID 1916264
  3. Rejuvenating nerve cells in adults. Chiu H, et al. Aging (Albany NY), 2013 Jul. PMID 23852222, Free PMC Article
  4. The C. elegans gene pan-1 encodes novel transmembrane and cytoplasmic leucine-rich repeat proteins and promotes molting and the larva to adult transition. Gissendanner CR, et al. BMC Dev Biol, 2013 May 17. PMID 23682709, Free PMC Article
  5. Heterochronic control of AFF-1-mediated cell-to-cell fusion in C. elegans. Friedlander-Shani L, et al. Adv Exp Med Biol, 2011. PMID 21432011

See all (108) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A branched heterochronic pathway directs juvenile-to-adult transition through two LIN-29 isoforms.
    Title: A branched heterochronic pathway directs juvenile-to-adult transition through two LIN-29 isoforms.
  2. New Roles for the Heterochronic Transcription Factor LIN-29 in Cuticle Maintenance and Lipid Metabolism at the Larval-to-Adult Transition in Caenorhabditis elegans.
    Title: New Roles for the Heterochronic Transcription Factor LIN-29 in Cuticle Maintenance and Lipid Metabolism at the Larval-to-Adult Transition in Caenorhabditis elegans.
  3. MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans.
    Title: MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cuticle pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male genitalia morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in molting cycle process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of vitellogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in programmed cell death involved in cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of basement membrane organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of basement membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of development, heterochronic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of nematode larval development, heterochronic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
C2H2-type domain-containing protein;Zinc finger transcription factor lin-29
NP_001122649.1
  • Confirmed by transcript evidence
NP_001254324.1
  • Confirmed by transcript evidence
NP_001391103.1
  • Confirmed by transcript evidence
NP_001407498.1
  • Confirmed by transcript evidence
NP_001407499.1
  • Confirmed by transcript evidence
NP_001407500.1
  • Confirmed by transcript evidence
NP_001407501.1
  • Confirmed by transcript evidence
NP_001407502.1
  • Confirmed by transcript evidence
NP_001407503.1
  • Confirmed by transcript evidence
NP_001407504.1
  • Confirmed by transcript evidence
NP_001407505.1
  • Confirmed by transcript evidence
NP_001407506.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11917643..11935340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001404245.1 → NP_001391103.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QGF3

  2. NM_001129177.4 → NP_001122649.1  Zinc finger transcription factor lin-29 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122649.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E6N0V9, G5EGB2, G5EGU6
    Conserved Domains (4) summary
    sd00017
    Location:149 → 169
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:178 → 198
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:190 → 217
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:177 → 261
    zf-C2H2_8; C2H2-type zinc ribbon

  3. NM_001420596.1 → NP_001407498.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4Q999

  4. NM_001420597.1 → NP_001407500.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QF14

  5. NM_001420598.1 → NP_001407502.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QBR1

  6. NM_001420599.1 → NP_001407499.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QAV3

  7. NM_001420600.1 → NP_001407501.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QD13

  8. NM_001420601.1 → NP_001407503.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QB12

  9. NM_001420602.1 → NP_001407504.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QF65

  10. NM_001267395.3 → NP_001254324.1  Zinc finger transcription factor lin-29 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254324.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6N0V9
    Conserved Domains (4) summary
    sd00017
    Location:11 → 31
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:40 → 60
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:52 → 79
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:39 → 123
    zf-C2H2_8; C2H2-type zinc ribbon

  11. NM_001420603.1 → NP_001407505.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QD26

  12. NM_001420604.1 → NP_001407506.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QBS8
Nucleotide Protein
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