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Y17G7B.3 hydroxyacylglutathione hydrolase [ Caenorhabditis elegans ]

Gene ID: 174839, updated on 2-Nov-2024

Summary

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Official Symbol
Y17G7B.3
Official Full Name
hydroxyacylglutathione hydrolase
Primary source
WormBase:WBGene00012459
Locus tag
CELE_Y17G7B.3
See related
AllianceGenome:WB:WBGene00012459
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hydroxyacylglutathione hydrolase activity. Predicted to be involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Orthologous to several human genes including HAGH (hydroxyacylglutathione hydrolase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Y17G7B.3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (11989024..11992049)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene BZIP domain-containing protein;Regulator of rDNA transcription 14 Neighboring gene BZIP domain-containing protein Neighboring gene B30.2/SPRY domain-containing protein;Set1/Ash2 histone methyltransferase complex subunit ash-2 Neighboring gene Deoxyhypusine synthase Neighboring gene Activin_recp domain-containing protein;DUF281 domain-containing protein Neighboring gene DNA replication licensing factor MCM2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
  2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxyacylglutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxyacylglutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hydroxyacylglutathione hydrolase
NP_496556.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11989024..11992049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064155.6 → NP_496556.1  hydroxyacylglutathione hydrolase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496556.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XXJ1
    Conserved Domains (1) summary
    PLN02469
    Location:12 → 260
    PLN02469; hydroxyacylglutathione hydrolase
Nucleotide Protein
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