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dhps-1 Deoxyhypusine synthase [ Caenorhabditis elegans ]

Gene ID: 174840, updated on 2-Nov-2024

Summary

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Official Symbol
dhps-1
Official Full Name
Deoxyhypusine synthase
Primary source
WormBase:WBGene00012460
Locus tag
CELE_Y17G7B.4
See related
AllianceGenome:WB:WBGene00012460
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable deoxyhypusine synthase activity. Predicted to be involved in spermidine metabolic process. Predicted to be active in cytoplasm. Orthologous to human DHPS (deoxyhypusine synthase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dhps-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (11993001..11998009)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene BZIP domain-containing protein Neighboring gene B30.2/SPRY domain-containing protein;Set1/Ash2 histone methyltransferase complex subunit ash-2 Neighboring gene hydroxyacylglutathione hydrolase Neighboring gene Activin_recp domain-containing protein;DUF281 domain-containing protein Neighboring gene DNA replication licensing factor MCM2 Neighboring gene Globin domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy. Fievet BT, et al. Nat Cell Biol, 2013 Jan. PMID 23242217, Free PMC Article
  2. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
  3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables deoxyhypusine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deoxyhypusine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-lysine modification to peptidyl-hypusine IEA
Inferred from Electronic Annotation
more info
  
involved_in spermidine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Deoxyhypusine synthase
NP_496557.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11993001..11998009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064156.6 → NP_496557.1  Deoxyhypusine synthase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496557.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XXJ0
    Conserved Domains (1) summary
    pfam01916
    Location:52 → 359
    DS; Deoxyhypusine synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XXJ0.1

Gene LinkOut

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