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cyn-16 Spliceosome-associated protein CWC27 homolog [ Caenorhabditis elegans ]

Gene ID: 174843, updated on 2-Nov-2024

Summary

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Official Symbol
cyn-16
Official Full Name
Spliceosome-associated protein CWC27 homolog
Primary source
WormBase:WBGene00000892
Locus tag
CELE_Y17G7B.9
See related
AllianceGenome:WB:WBGene00000892
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome. Is expressed in intestine and ventral cord neurons. Orthologous to human CWC27 (CWC27 spliceosome associated cyclophilin). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cyn-16 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (12028128..12036742, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Globin domain-containing protein Neighboring gene ncRNA Neighboring gene RNA exonuclease 4 Neighboring gene F-box domain-containing protein Neighboring gene Triosephosphate isomerase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel cyclophilin from parasitic and free-living nematodes with a unique substrate- and drug-binding domain. Ma D, et al. J Biol Chem, 2002 Apr 26. PMID 11847225
  2. Identification and comparative analysis of the peptidyl-prolyl cis/trans isomerase repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe. Pemberton TJ, et al. Comp Funct Genomics, 2005. PMID 18629211, Free PMC Article
  3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Spliceosome-associated protein CWC27 homolog
NP_496562.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    12028128..12036742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064161.7 → NP_496562.3  Spliceosome-associated protein CWC27 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496562.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XXI7
    Conserved Domains (2) summary
    PRK14906
    Location:258 → 353
    PRK14906; DNA-directed RNA polymerase subunit beta'
    cd01925
    Location:8 → 175
    cyclophilin_CeCYP16-like; cyclophilin-type peptidylprolyl cis- trans isomerase) (PPIase) domain similar to Caenorhabditis elegans cyclophilin 16. C. elegans CeCYP-16, compared to the archetypal cyclophilin Human cyclophilin A has, a reduced peptidylprolyl cis- trans isomerase ...
Nucleotide Protein
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