U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

tpi-1 Triosephosphate isomerase [ Caenorhabditis elegans ]

Gene ID: 174844, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
tpi-1
Official Full Name
Triosephosphate isomerase
Primary source
WormBase:WBGene00006601
Locus tag
CELE_Y17G7B.7
See related
AllianceGenome:WB:WBGene00006601
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable triose-phosphate isomerase activity. Involved in cell redox homeostasis and determination of adult lifespan. Located in myofibril. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Orthologous to human TPI1 (triosephosphate isomerase 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See tpi-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (12036835..12039139, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene RNA exonuclease 4 Neighboring gene F-box domain-containing protein Neighboring gene Spliceosome-associated protein CWC27 homolog Neighboring gene ncRNA Neighboring gene Inositol-pentakisphosphate 2-kinase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Seven newly discovered intron positions in the triose-phosphate isomerase gene: evidence for the introns-late theory. Logsdon JM Jr, et al. Proc Natl Acad Sci U S A, 1995 Aug 29. PMID 7667320, Free PMC Article
  2. Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress. Ralser M, et al. J Biol, 2007 Dec 21. PMID 18154684, Free PMC Article
  3. Mining nematode protein secretomes to explain lifestyle and host specificity. Tritten L, et al. PLoS Negl Trop Dis, 2021 Sep. PMID 34587193, Free PMC Article
  4. Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Dong MQ, et al. Science, 2007 Aug 3. PMID 17673661
  5. Glyceraldehyde-3-phosphate dehydrogenase mediates anoxia response and survival in Caenorhabditis elegans. Mendenhall AR, et al. Genetics, 2006 Nov. PMID 16980394, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables methylglyoxal synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables triose-phosphate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables triose-phosphate isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in glyceraldehyde-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myofibril HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Triosephosphate isomerase
NP_001366651.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    12036835..12039139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381623.3 → NP_001366651.1  Triosephosphate isomerase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10657, Q9U2R2
    Conserved Domains (1) summary
    PTZ00333
    Location:1 → 245
    PTZ00333; triosephosphate isomerase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10657.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools