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Y57A10A.31 RING-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174872, updated on 2-Nov-2024

Summary

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Official Symbol
Y57A10A.31
Official Full Name
RING-type domain-containing protein
Primary source
WormBase:WBGene00013270
Locus tag
CELE_Y57A10A.31
See related
AllianceGenome:WB:WBGene00013270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin binding activity and ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein linear polyubiquitination. Predicted to be part of LUBAC complex. Human ortholog(s) of this gene implicated in Gordon Holmes syndrome. Orthologous to human RNF216 (ring finger protein 216). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Y57A10A.31 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (12289385..12300573)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Succinate dehydrogenase assembly factor 2, mitochondrial Neighboring gene Eukaryotic translation initiation factor 4E-5 Neighboring gene Dof-type domain-containing protein Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein linear polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of LUBAC complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RING-type domain-containing protein
NP_496609.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    12289385..12300573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064208.3 → NP_496609.2  RING-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496609.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NA71
    Conserved Domains (3) summary
    smart00647
    Location:882 → 946
    IBR; In Between Ring fingers
    cl17238
    Location:803 → 832
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl19760
    Location:970 → 1011
    IBR; IBR domain, a half RING-finger domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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