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tbc-17 CRC domain-containing protein;Rab-GAP TBC domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174900, updated on 2-Nov-2024

Summary

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Official Symbol
tbc-17
Official Full Name
CRC domain-containing protein;Rab-GAP TBC domain-containing protein
Primary source
WormBase:WBGene00012894
Locus tag
CELE_Y46G5A.1
See related
AllianceGenome:WB:WBGene00012894
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activator activity. Orthologous to several human genes including USP6NL (USP6 N-terminal like). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tbc-17 in Genome Data Viewer
Location:
chromosome: II
Exon count:
18
Sequence:
Chromosome: II; NC_003280.10 (12694412..12725566)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Heme O synthase Neighboring gene U5 small nuclear ribonucleoprotein 200 kDa helicase Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequencing of C. elegans balancer strains reveals previously unappreciated complex genomic rearrangements. Maroilley T, et al. Genome Res, 2023 Jan. PMID 36617680, Free PMC Article
  2. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article
  3. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
  4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CRC domain-containing protein;Rab-GAP TBC domain-containing protein
NP_001022434.2
  • Confirmed by transcript evidence
NP_001022435.2
  • Confirmed by transcript evidence
NP_001254355.1
  • Confirmed by transcript evidence
NP_001254356.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    12694412..12725566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027263.7 → NP_001022434.2  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022434.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U2D8
    Conserved Domains (1) summary
    smart00164
    Location:577 → 788
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  2. NM_001027264.8 → NP_001022435.2  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022435.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K711
    Conserved Domains (1) summary
    smart00164
    Location:577 → 788
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  3. NM_001267426.3 → NP_001254355.1  CRC domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254355.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1UBJ3

  4. NM_001267427.5 → NP_001254356.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254356.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7FAS5
    Conserved Domains (1) summary
    smart00164
    Location:281 → 492
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
Nucleotide Protein
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