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snrp-200 U5 small nuclear ribonucleoprotein 200 kDa helicase [ Caenorhabditis elegans ]

Gene ID: 174901, updated on 2-Nov-2024

Summary

Official Symbol
snrp-200
Official Full Name
U5 small nuclear ribonucleoprotein 200 kDa helicase
Primary source
WormBase:WBGene00012896
Locus tag
CELE_Y46G5A.4
See related
AllianceGenome:WB:WBGene00012896
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA helicase activity. Predicted to be involved in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11). Predicted to be located in nucleus. Predicted to be part of spliceosomal complex. Is expressed in excretory cell; gonad; head ganglion; intestine; and pharynx. Used to study retinitis pigmentosa 33. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 33. Orthologous to human SNRNP200 (small nuclear ribonucleoprotein U5 subunit 200). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See snrp-200 in Genome Data Viewer
Location:
chromosome: II
Exon count:
12
Sequence:
Chromosome: II; NC_003280.10 (12726963..12736910, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Heme O synthase Neighboring gene CRC domain-containing protein;Rab-GAP TBC domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene CDP-diacylglycerol--inositol 3-phosphatidyltransferase Neighboring gene pseudo

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 
part_of spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
U5 small nuclear ribonucleoprotein 200 kDa helicase
NP_001366952.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    12726963..12736910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381632.2NP_001366952.1  U5 small nuclear ribonucleoprotein 200 kDa helicase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U2G0
    Conserved Domains (5) summary
    smart00611
    Location:18082127
    SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
    COG1204
    Location:4381234
    BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
    PRK00254
    Location:13131878
    PRK00254; ski2-like helicase; Provisional
    cd18021
    Location:13191509
    DEXHc_Brr2_2; C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase
    pfam18149
    Location:254359
    Helicase_PWI; N-terminal helicase PWI domain