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zyx-1 Zyxin [ Caenorhabditis elegans ]

Gene ID: 174951, updated on 2-Nov-2024

Summary

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Official Symbol
zyx-1
Official Full Name
Zyxin
Primary source
WormBase:WBGene00006999
Locus tag
CELE_F42G4.3
See related
AllianceGenome:WB:WBGene00006999
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DEAD/H-box RNA helicase binding activity. Involved in maintenance of synapse structure. Acts upstream of or within with a positive effect on smooth muscle contraction. Located in M band; nucleus; and striated muscle dense body. Is expressed in several structures, including intestine; muscle cell; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to several human genes including LPP (LIM domain containing preferred translocation partner in lipoma) and TRIP6 (thyroid hormone receptor interactor 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See zyx-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
12
Sequence:
Chromosome: II; NC_003280.10 (13057152..13071513)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Noncompact myelin-associated protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Alternative N-terminal open reading frame of ZYX-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NR LBD domain-containing protein Neighboring gene YDG domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ZYX-1/Zyxin plays a minor role in oocyte transit through the spermatheca in C. elegans. Castaneda PG, et al. MicroPubl Biol, 2021. PMID 34703987, Free PMC Article
  2. The conserved LIM domain-containing focal adhesion protein ZYX-1 regulates synapse maintenance in Caenorhabditis elegans. Luo S, et al. Development, 2014 Oct. PMID 25252943, Free PMC Article
  3. Zyxin contributes to coupling between cell junctions and contractile actomyosin networks during apical constriction. Slabodnick MM, et al. PLoS Genet, 2023 Mar. PMID 36976799, Free PMC Article
  4. Synaptic branch stability is mediated by non-enzymatic functions of MEC-17/αTAT1 and ATAT-2. Teoh JS, et al. Sci Rep, 2022 Aug 17. PMID 35977998, Free PMC Article
  5. azyx-1 is a new gene that overlaps with zyxin and affects its translation in C. elegans, impacting muscular integrity and locomotion. Parmar BS, et al. PLoS Biol, 2023 Sep. PMID 37713439, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. azyx-1 is a new gene that overlaps with zyxin and affects its translation in C. elegans, impacting muscular integrity and locomotion.
    Title: azyx-1 is a new gene that overlaps with zyxin and affects its translation in C. elegans, impacting muscular integrity and locomotion.
  2. ZYX-1 is a conserved LIM domain-containing focal adhesion protein that regulates synapse maintenance in Caenorhabditis elegans
    Title: The conserved LIM domain-containing focal adhesion protein ZYX-1 regulates synapse maintenance in Caenorhabditis elegans.
  3. The zyx-1 gene encodes two different isoforms, ZYX-1a and ZYX-1b, which exhibit different roles in dystrophin-dependent muscle degeneration in C. elegans
    Title: ZYX-1, the unique zyxin protein of Caenorhabditis elegans, is involved in dystrophin-dependent muscle degeneration.
  4. DYC-1 interacts with ZYX-1, the homologue of the vertebrate focal adhesion LIM domain protein zyxin.
    Title: DYC-1, a protein functionally linked to dystrophin in Caenorhabditis elegans is associated with the dense body, where it interacts with the muscle LIM domain protein ZYX-1.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DEAD/H-box RNA helicase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of synapse structure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within_positive_effect smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in M band IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in striated muscle dense body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Zyxin
NP_001254364.1
  • Confirmed by transcript evidence
NP_001254365.1
  • Confirmed by transcript evidence
NP_001254366.1
  • Confirmed by transcript evidence
NP_496776.1
  • Confirmed by transcript evidence
NP_496777.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    13057152..13071513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267435.4 → NP_001254364.1  Zyxin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254364.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U3F4
    Conserved Domains (1) summary
    cl02475
    Location:531 → 595
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. NM_064375.10 → NP_496776.1  Zyxin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496776.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2L2F5, H2L2F6, H2L2F7, Q9U3F4, Q9U3F5
    Conserved Domains (2) summary
    cd09357
    Location:531 → 593
    LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
    cl02475
    Location:471 → 530
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. NM_001267436.3 → NP_001254365.1  Zyxin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254365.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U3F4
    Conserved Domains (2) summary
    cd09357
    Location:265 → 327
    LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
    cl02475
    Location:205 → 264
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  4. NM_001267437.3 → NP_001254366.1  Zyxin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254366.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U3F4
    Conserved Domains (2) summary
    cd09357
    Location:173 → 235
    LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
    cl02475
    Location:113 → 172
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  5. NM_064376.6 → NP_496777.2  Zyxin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496777.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U3F4
    Conserved Domains (2) summary
    cd09357
    Location:128 → 190
    LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
    cl02475
    Location:68 → 127
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U3F4.1

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