mecr-1 Enoyl-[acyl-carrier-protein] reductase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: mecr-1
Official Full Name: Enoyl-[acyl-carrier-protein] reductase, mitochondrial
Primary source: WormBase:WBGene00012375
Locus tag: CELE_W09H1.5
See related: AllianceGenome:WB:WBGene00012375
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable enoyl-[acyl-carrier-protein] reductase (NADPH) activity. Predicted to be involved in fatty acid metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including intestine; nervous system; pharynx; tail; and vulval muscle. Human ortholog(s) of this gene implicated in childhood-onset dystonia with optic atrophy and basal ganglia abnormalities and optic atrophy. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See mecr-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003280.10 (13185987..13187314, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

W09H1.5 (e-PCR)
- UniSTS:306100

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables enoyl-[acyl-carrier-protein] reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Enoyl-[acyl-carrier-protein] reductase, mitochondrial

NP_496800.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

13185987..13187314 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064399.5 → NP_496800.1 Enoyl-[acyl-carrier-protein] reductase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496800.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45903

Conserved Domains (2) summary

cd08290
Location:17 → 343

ETR; 2-enoyl thioester reductase (ETR)

COG1064
Location:21 → 343

AdhP; D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family [Carbohydrate transport and metabolism]