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efl-2 Transcription factor efl-2 [ Caenorhabditis elegans ]

Gene ID: 174980, updated on 2-Nov-2024

Summary

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Official Symbol
efl-2
Official Full Name
Transcription factor efl-2
Primary source
WormBase:WBGene00001162
Locus tag
CELE_Y48C3A.17
See related
AllianceGenome:WB:WBGene00001162
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in dorsal nerve cord; head muscle; intestine; spermatheca; and ventral nerve cord. Orthologous to human E2F6 (E2F transcription factor 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See efl-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (13406140..13411895)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase Neighboring gene Peptidyl-prolyl cis-trans isomerase Neighboring gene Threonylcarbamoyl-AMP synthase Neighboring gene Centromere protein S;Eukaryotic translation initiation factor 3 30 kDa subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dispersed crude oil amplifies germ cell apoptosis in Caenorhabditis elegans, followed a CEP-1-dependent pathway. Polli JR, et al. Arch Toxicol, 2014 Mar. PMID 24496467
  2. From the Cover: ZnO Nanoparticles Enhanced Germ Cell Apoptosis in Caenorhabditis elegans, in Comparison with ZnCl2. O'Donnell B, et al. Toxicol Sci, 2017 Apr 1. PMID 28003440, Free PMC Article
  3. C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions. Schertel C, et al. Development, 2007 Oct. PMID 17881492
  4. Detection of Caenorhabditis elegans Germ Cell Apoptosis Following Exposure to Environmental Contaminant Mixtures: A Crude Oil-Dispersant Mixture Example. Polli JR, et al. Methods Mol Biol, 2021. PMID 34097257
  5. C. elegans class B synthetic multivulva genes act in G(1) regulation. Boxem M, et al. Curr Biol, 2002 Jun 4. PMID 12062054

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Transcription factor efl-2
NP_001122658.1
  • Confirmed by transcript evidence
NP_001122660.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    13406140..13411895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129188.4 → NP_001122660.1  Transcription factor efl-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122660.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5HWA6, A5HWA8, Q9BIE8
    Conserved Domains (3) summary
    cd14660
    Location:105 → 140
    E2F_DD; coiled coil [structural motif]
    pfam02319
    Location:40 → 99
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    cl22411
    Location:110 → 200
    E2F_DD; Dimerization domain of E2F transcription factors

  2. NM_001129186.3 → NP_001122658.1  Transcription factor efl-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122658.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5HWA6
    Conserved Domains (3) summary
    cd14660
    Location:105 → 140
    E2F_DD; coiled coil [structural motif]
    pfam02319
    Location:37 → 99
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    cl22411
    Location:110 → 200
    E2F_DD; Dimerization domain of E2F transcription factors
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A5HWA8.1

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