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phdh-1 D-3-phosphoglycerate dehydrogenase [ Caenorhabditis elegans ]

Gene ID: 175012, updated on 2-Nov-2024

Summary

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Official Symbol
phdh-1
Official Full Name
D-3-phosphoglycerate dehydrogenase
Primary source
WormBase:WBGene00007836
Locus tag
CELE_C31C9.2
See related
AllianceGenome:WB:WBGene00007836
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphoglycerate dehydrogenase activity. Is expressed in hypodermis; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 1; PHGDH deficiency; and amino acid metabolic disorder. Orthologous to human PHGDH (phosphoglycerate dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See phdh-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (13636869..13638480, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Glutathione S-Transferase Neighboring gene GST C-terminal domain-containing protein Neighboring gene Glutathione S-transferase Neighboring gene DPPIV_N domain-containing protein;Protein TolB;Translocation protein TolB Neighboring gene F-box domain-containing protein Neighboring gene pseudo Neighboring gene F-box domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The effect of repeated isoflurane exposure on serine synthesis pathway during the developmental period in Caenorhabditis elegans. Do SH, et al. Neurotoxicology, 2019 Mar. PMID 30639121
  2. Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis. Lionaki E, et al. Nat Commun, 2022 Feb 3. PMID 35115503, Free PMC Article
  3. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
  4. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
  5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables phosphoglycerate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
D-3-phosphoglycerate dehydrogenase
NP_001408274.1
  • Confirmed by transcript evidence
NP_496868.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    13636869..13638480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064467.6 → NP_496868.1  D-3-phosphoglycerate dehydrogenase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496868.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17626
    Conserved Domains (2) summary
    COG0111
    Location:4 → 309
    SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
    cd12173
    Location:7 → 309
    PGDH_4; Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains

  2. NM_001421351.1 → NP_001408274.1  D-3-phosphoglycerate dehydrogenase [Caenorhabditis elegans]

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

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