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his-16 Histone H2A [ Caenorhabditis elegans ]

Gene ID: 175025, updated on 2-Nov-2024

Summary

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Official Symbol
his-16
Official Full Name
Histone H2A
Primary source
WormBase:WBGene00001890
Locus tag
CELE_ZK131.10
See related
AllianceGenome:WB:WBGene00001890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Involved in defense response to Gram-negative bacterium and innate immune response. Predicted to be part of nucleosome. Orthologous to several human genes including H2AX (H2A.X variant histone). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See his-16 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003280.10 (13817760..13818143, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Neogenin_C domain-containing protein;TORC_N domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Histone H2B 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleotide sequences of Caenorhabditis elegans core histone genes. Genes for different histone classes share common flanking sequence elements. Roberts SB, et al. J Mol Biol, 1989 Apr 20. PMID 2544730
  2. Evidence for dynamic alteration in histone gene clusters of Caenorhabditis elegans: a topoisomerase II connection? Holt SJ, et al. Genet Res, 2002 Feb. PMID 11974600
  3. Structural Insights into ceNAP1 Chaperoning Activity toward ceH2A-H2B. Liu Y, et al. Structure, 2019 Dec 3. PMID 31653339
  4. Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans. Gaeta AL, et al. PLoS Genet, 2022 Aug. PMID 35984862, Free PMC Article
  5. The Caenorhabditis elegans histone hairpin-binding protein is required for core histone gene expression and is essential for embryonic and postembryonic cell division. Pettitt J, et al. J Cell Sci, 2002 Feb 15. PMID 11865041

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Histone H2A
NP_496887.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    13817760..13818143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064486.5 → NP_496887.1  Histone H2A [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496887.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P09588, Q7JKF5
    Conserved Domains (1) summary
    PTZ00017
    Location:18 → 127
    PTZ00017; histone H2A; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09588.2

Gene LinkOut

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