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cyp-37A1 CYtochrome P450 family [ Caenorhabditis elegans ]

Gene ID: 175053, updated on 2-Nov-2024

Summary

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Official Symbol
cyp-37A1
Official Full Name
CYtochrome P450 family
Primary source
WormBase:WBGene00008499
Locus tag
CELE_F01D5.9
See related
AllianceGenome:WB:WBGene00008499
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Predicted to be located in membrane. Is expressed in intestine; nervous system; pharyngeal-intestinal valve; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cyp-37A1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (14013826..14016965, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene TPM domain-containing protein Neighboring gene ncRNA Neighboring gene Serine aminopeptidase S33 domain-containing protein Neighboring gene Serine aminopeptidase S33 domain-containing protein Neighboring gene Carbohydrate sulfotransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CYP4V2 fatty acid omega hydroxylase, a druggable target for the treatment of metabolic associated fatty liver disease (MAFLD). Osborne N, et al. Biochem Pharmacol, 2022 Jan. PMID 34798124
  2. Specific regulation of thermosensitive lipid droplet fusion by a nuclear hormone receptor pathway. Li S, et al. Proc Natl Acad Sci U S A, 2017 Aug 15. PMID 28760992, Free PMC Article
  3. Dietary and environmental factors have opposite AhR-dependent effects on C. elegans healthspan. Brinkmann V, et al. Aging (Albany NY), 2020 Dec 13. PMID 33349622, Free PMC Article
  4. Caenorhabditis elegans genomic response to soil bacteria predicts environment-specific genetic effects on life history traits. Coolon JD, et al. PLoS Genet, 2009 Jun. PMID 19503598, Free PMC Article
  5. Eicosapentaenoic acid influences the pathogenesis of Candida albicans in Caenorhabditis elegans via inhibition of hyphal formation and stimulation of the host immune response. Mokoena NZ, et al. Med Microbiol Immunol, 2023 Oct. PMID 37672050, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CYtochrome P450 family
NP_496939.2
  • Product from WormBase gene class cyp;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14013826..14016965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064538.4 → NP_496939.2  CYtochrome P450 family [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496939.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XVA6
    Conserved Domains (1) summary
    pfam00067
    Location:41 → 503
    p450; Cytochrome P450
Nucleotide Protein
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