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K09E4.4 Alpha-N-acetylglucosaminidase [ Caenorhabditis elegans ]

Gene ID: 175063, updated on 2-Nov-2024

Summary

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Official Symbol
K09E4.4
Official Full Name
Alpha-N-acetylglucosaminidase
Primary source
WormBase:WBGene00010722
Locus tag
CELE_K09E4.4
See related
AllianceGenome:WB:WBGene00010722
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Used to study mucopolysaccharidosis. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2V; mucopolysaccharidosis III; and mucopolysaccharidosis type IIIB. Orthologous to human NAGLU (N-acetyl-alpha-glucosaminidase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See K09E4.4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (14114213..14118110, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene BK channel Interacting Protein Neighboring gene G protein-coupled receptor Neighboring gene Chondroitin proteoglycan 7 Neighboring gene Arginine-hydroxylase NDUFAF5, mitochondrial Neighboring gene Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

General protein information

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Preferred Names
Alpha-N-acetylglucosaminidase
NP_496948.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14114213..14118110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064547.7 → NP_496948.2  Alpha-N-acetylglucosaminidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496948.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NAP6
    Conserved Domains (2) summary
    pfam05089
    Location:136 → 474
    NAGLU; Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain
    pfam12972
    Location:481 → 710
    NAGLU_C; Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain
Nucleotide Protein
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